Efficient and Size-Controllable Method and Mechanism for Preparing Cellulose Nanospheres

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomacromolecules Pub Date : 2025-04-14 Epub Date: 2025-03-05 DOI:10.1021/acs.biomac.5c00103

Weixiong Zhao , Yuhang Zhou , Guichao Zhang, Yue Li, Zixuan Liao, Gaorong Lai, Yongze Jiang, Shanshan Jia, Zhiping Su, Jinqiu Qi, Shaobo Zhang

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Abstract

Cellulose nanosphere (CNS), reported as a novel cellulose material, has encountered significant challenges in achieving efficient and size-controllable preparation, which has considerably constrained its development. In this study, we have developed an innovative and size-controllable method that synthesizes CNS within only 7 min. A detailed investigation into the morphology, chemical structure, and crystalline structure of CNS was conducted, leading to the proposal of a formation mechanism for CNS. The mechanism is described as follows: cellulose dissolution, hydrophobic triethoxymethylsilane hydrolysis, condensation nucleation in supersaturation, growth through hydrogen-bonding interactions and condensation, and CNS forms in the critical supersaturation. The supersaturation level was controlled by adjusting the stirring speed, thus realizing the size-controllable preparation of CNS and verifying the proposed mechanism. The results demonstrate that the particle size of CNS increases from 63.4 ± 14.0 nm to 108.6 ± 27.1 nm as the stirring speed decreases from 1000 r/min to 300 r/min.

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制备纤维素纳米微球的高效、粒径可控的方法和机理。

纤维素纳米球（Cellulose nanosphere， CNS）作为一种新型的纤维素材料，在实现高效和粒径可控的制备方面遇到了很大的挑战，这在很大程度上制约了其发展。在这项研究中，我们开发了一种创新的、尺寸可控的方法，在7分钟内合成了CNS。我们对CNS的形态、化学结构和晶体结构进行了详细的研究，并提出了CNS的形成机制。其机理为：纤维素溶解、疏水三乙氧基甲基硅烷水解、过饱和条件下的缩合成核、通过氢键相互作用和缩合生长、临界过饱和条件下形成CNS。通过调节搅拌速度来控制过饱和水平，从而实现了CNS的粒度可控制备，验证了所提机理。结果表明：当搅拌速度从1000 r/min降低到300 r/min时，CNS的粒径从63.4±14.0 nm增大到108.6±27.1 nm；

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.