Ocular surface side effects of botulinum toxin type A injections in the treatment of lateral canthal wrinkles (Crow’s Feet)

IF 3.7 3区医学 Q1 OPHTHALMOLOGY Contact Lens & Anterior Eye Pub Date : 2025-07-01 Epub Date: 2025-03-03 DOI:10.1016/j.clae.2025.102389

Jiaxin Han , Xue Yang , Qianwen Gong , Tingting Liu , Huifang Tu , Xiulan Lu , Fan Yang , Ruiting Ji , Liang Hu

{"title":"Ocular surface side effects of botulinum toxin type A injections in the treatment of lateral canthal wrinkles (Crow’s Feet)","authors":"Jiaxin Han , Xue Yang , Qianwen Gong , Tingting Liu , Huifang Tu , Xiulan Lu , Fan Yang , Ruiting Ji , Liang Hu","doi":"10.1016/j.clae.2025.102389","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>This study investigates the impact of Botulinum Toxin Type A (BoNT-A) injections for lateral canthal wrinkles on the ocular surface.</div></div><div><h3>Methods</h3><div>A total of 30 patients (30 eyes) who received BoNT-A injections were followed over a three-month period. Evaluations included tear meniscus height (TMH), strip meniscometry test, fluorescein tear film break-up time (FTBUT), corneal staining score, meibomian gland orifice and meibum quality score. Observations were recorded at baseline, one week, one month, and three months post-injection.</div></div><div><h3>Results</h3><div>Upper and total eyelid meiboscore, meibomian gland orifice obstruction, and meibum quality score peaked at three months post-injection, while FTBUT was shortest during the same period, with significant differences observed across time points (P < 0.05). Post-hoc analysis indicated a significant reduction in FTBUT between baseline and three months (P = 0.048). Corneal staining scores were highest at one week, with significant differences across time points (P < 0.001); post-hoc analysis revealed a significant difference between one week and three months (P = 0.037). No significant changes were found in TMH or strip meniscometry test score (P = 0.374, P = 0.732).</div></div><div><h3>Conclusions</h3><div>BoNT-A injections may temporarily compromise ocular surface stability by decreasing tear film stability, disrupting meibomian gland function, and causing corneal epithelial disruption.</div></div>","PeriodicalId":49087,"journal":{"name":"Contact Lens & Anterior Eye","volume":"48 4","pages":"Article 102389"},"PeriodicalIF":3.7000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Contact Lens & Anterior Eye","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1367048425000232","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/3/3 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose

This study investigates the impact of Botulinum Toxin Type A (BoNT-A) injections for lateral canthal wrinkles on the ocular surface.

Methods

A total of 30 patients (30 eyes) who received BoNT-A injections were followed over a three-month period. Evaluations included tear meniscus height (TMH), strip meniscometry test, fluorescein tear film break-up time (FTBUT), corneal staining score, meibomian gland orifice and meibum quality score. Observations were recorded at baseline, one week, one month, and three months post-injection.

Results

Upper and total eyelid meiboscore, meibomian gland orifice obstruction, and meibum quality score peaked at three months post-injection, while FTBUT was shortest during the same period, with significant differences observed across time points (P < 0.05). Post-hoc analysis indicated a significant reduction in FTBUT between baseline and three months (P = 0.048). Corneal staining scores were highest at one week, with significant differences across time points (P < 0.001); post-hoc analysis revealed a significant difference between one week and three months (P = 0.037). No significant changes were found in TMH or strip meniscometry test score (P = 0.374, P = 0.732).

Conclusions

BoNT-A injections may temporarily compromise ocular surface stability by decreasing tear film stability, disrupting meibomian gland function, and causing corneal epithelial disruption.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

A型肉毒毒素注射治疗侧眦皱纹（鱼尾纹）的眼表副作用。

目的：探讨A型肉毒毒素（BoNT-A）注射治疗眼表侧眦皱纹的效果。方法：对30例接受BoNT-A注射的患者（30只眼）进行为期3个月的随访。评估方法包括撕裂半月板高度（TMH）、条形半月板测量法、荧光素撕裂膜破裂时间（FTBUT）、角膜染色评分、睑板腺孔口和睑板质量评分。记录注射后基线、1周、1个月和3个月的观察结果。结果：上睑和全睑meiboscore、睑腺孔梗阻、睑质量评分均在注射后3个月达到高峰，FTBUT同期最短，各时间点差异有统计学意义（P < 0.05）。事后分析显示FTBUT在基线和三个月之间显著降低（P = 0.048）。角膜染色评分在第一周时最高，各时间点差异有统计学意义（P < 0.001）；事后分析显示，1周和3个月之间存在显著差异（P = 0.037）。TMH和条形半月线测试评分无显著变化（P = 0.374, P = 0.732）。结论：BoNT-A注射可能会通过降低泪膜稳定性、破坏睑板腺功能和引起角膜上皮破坏而暂时损害眼表稳定性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Contact Lens & Anterior Eye OPHTHALMOLOGY-

CiteScore

7.60

自引率

18.80%

发文量

198

审稿时长

55 days

期刊介绍： Contact Lens & Anterior Eye is a research-based journal covering all aspects of contact lens theory and practice, including original articles on invention and innovations, as well as the regular features of: Case Reports; Literary Reviews; Editorials; Instrumentation and Techniques and Dates of Professional Meetings.