Beata Bień, Piotr K Krajewski, Jacek C Szepietowski
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引用次数: 0
Abstract
Introduction: Psoriasis is a chronic inflammatory skin disease affecting over 60 million people worldwide, often linked to comorbidities such as psoriatic arthritis and cardiovascular disease. Beyond physical symptoms, psoriasis can significantly impact major life-changing decisions (MLCDs), leading to long-term consequences and missed opportunities. This study focused on assessing MLCDs and their correlations with quality of life (QoL), disease acceptance, and itch severity, emphasizing the need for early intervention to mitigate cumulative life course impairment.
Methods: A total of 166 consecutive patients with psoriasis, comprising 101 men and 65 women, all with a minimum disease duration of 1 year, were included in the study. Clinical and psychological aspects of psoriasis were thoroughly evaluated using a range of standardized instruments, along with a questionnaire collecting demographic data.
Results: Psoriasis affected at least one MLCD in 93.4% of patients, most commonly influencing decisions related to physical activity (77%), dietary habits (70%), smoking and alcohol consumption (58%), and job choices (30%). A significant correlation was found between the Major Life-Changing Decisions Profile (MLCDP) total score and QoL (r = 0.561, p < 0.001), psoriasis severity (r = 0.275, p < 0.001), and itch severity (r = 0.351, p < 0.001), as well as an inverse correlation with disease acceptance (r = - 0.545, p < 0.001).
Conclusion: Psoriasis may affect MLCDs, reflecting the long-term consequences of the disease. A comprehensive approach is essential to prevent these impacts, especially in cases of early-onset psoriasis.
期刊介绍：
Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.
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