{"title":"Arnebinfuranoids A–G, seven unique heterodimers of meroterpenoids from Arnebia euchroma","authors":"Ling-Hao Zhao, Hai-Wei Yan, Jian-Shuang Jiang, Xu Zhang, Ya-Nan Yang, Xiang Yuan, Pei-Cheng Zhang","doi":"10.1016/j.phytochem.2025.114461","DOIUrl":null,"url":null,"abstract":"<div><div>Seven previously undescribed heterodimers (<strong>1</strong>–<strong>7</strong>) with unusual carbon-carbon bond linkages for monomeric meroterpenoids and a known compound (<strong>8</strong>) were isolated from the roots of <em>Arnebia euchroma</em> (Royle) Johnst. Their structures were elucidated by extensive spectroscopic methods and quantum chemical calculations of electronic circular dichroism spectra. Further careful NMR analysis revealed that the chemical shift differences of the methylene protons affected by remote chirality were related to the relative configurations of the heterodimers (<strong>1</strong>–<strong>6</strong>). Compounds <strong>2</strong>–<strong>5</strong> and <strong>8</strong> significantly ameliorated PC12 cell damage induced by H<sub>2</sub>O<sub>2</sub> and glutamate <em>in vitro</em> comparable to edaravone.</div></div>","PeriodicalId":20170,"journal":{"name":"Phytochemistry","volume":"235 ","pages":"Article 114461"},"PeriodicalIF":3.2000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031942225000846","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Seven previously undescribed heterodimers (1–7) with unusual carbon-carbon bond linkages for monomeric meroterpenoids and a known compound (8) were isolated from the roots of Arnebia euchroma (Royle) Johnst. Their structures were elucidated by extensive spectroscopic methods and quantum chemical calculations of electronic circular dichroism spectra. Further careful NMR analysis revealed that the chemical shift differences of the methylene protons affected by remote chirality were related to the relative configurations of the heterodimers (1–6). Compounds 2–5 and 8 significantly ameliorated PC12 cell damage induced by H2O2 and glutamate in vitro comparable to edaravone.
期刊介绍：
Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.
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