Deep learning-based segmentation of the trigeminal nerve and surrounding vasculature in trigeminal neuralgia.

Abstract

Objective: Preoperative workup of trigeminal neuralgia (TN) consists of identification of neurovascular features on MRI. In this study, the authors apply and evaluate the performance of deep learning models for segmentation of the trigeminal nerve and surrounding vasculature to quantify anatomical features of the nerve and vessels.

Methods: Six U-Net-based neural networks, each with a different encoder backbone, were trained to label constructive interference in steady-state MRI voxels as nerve, vasculature, or background. A retrospective dataset of 50 TN patients at the authors' institution who underwent preoperative high-resolution MRI in 2022 was utilized to train and test the models. Performance was measured by the Dice coefficient and intersection over union (IoU) metrics. Anatomical characteristics, such as surface area of neurovascular contact and distance to the contact point, were computed and compared between the predicted and ground truth segmentations.

Results: Of the evaluated models, the best performing was U-Net with an SE-ResNet50 backbone (Dice score = 0.775 ± 0.015, IoU score = 0.681 ± 0.015). When the SE-ResNet50 backbone was used, the average surface area of neurovascular contact in the testing dataset was 6.90 mm2, which was not significantly different from the surface area calculated from manual segmentation (p = 0.83). The average calculated distance from the brainstem to the contact point was 4.34 mm, which was also not significantly different from manual segmentation (p = 0.29).

Conclusions: U-Net-based neural networks perform well for segmenting trigeminal nerve and vessels from preoperative MRI volumes. This technology enables the development of quantitative and objective metrics for radiographic evaluation of TN.