Effects of Oral supplementation with eggshell membrane (Ovoderm®-AS) on skin health: A randomized, double-blind, placebo-controlled trial

Abstract

Eggshell membrane (ESM, Ovoderm®-AS) contains bioactive compounds like collagen, elastin, hyaluronic acid, glucosamine, and chondroitin sulfate, which promote cellular activity, enhance collagen production, and reduce UV-induced damage. This double-blind, randomized, placebo-controlled trial evaluated the effects of oral ESM supplementation on skin parameters, including wrinkling, elasticity, dermal density, sagging, hydration, transepidermal water loss (TEWL), desquamation, roughness, and serum MMP-2 and MMP-9 levels. One hundred women aged 25–60 were randomized to receive 600 mg/day of ESM or placebo for 12 weeks, with assessments at baseline, 6 weeks, and 12 weeks. ESM significantly improved wrinkling, elasticity, dermal density, sagging, hydration, TEWL, desquamation, and roughness after 12 weeks (p < 0.05). Improvements in elasticity, dermal density, and sagging were observed as early as 6 weeks. No adverse events were reported. In conclusion, ESM is a safe and effective ingredient for improving skin health.