Quan H Pham, Van T K Nguyen, Nguyen-Nguyen Pham-Tran, Binh T D Trinh, Ly T T Nguyen, Le-Thu T Nguyen, Ngoc T T Pham, Lien-Hoa D Nguyen, Ngoc T N Ngo
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引用次数: 0
Abstract
A new nemoralisin-type diterpenoid, nemoralisin O (1), along with ten previously identified compounds, was obtained from Aglaia lawii bark. Structural characterisation was performed using various spectroscopic techniques, with a focus on 1D and 2D NMR, and HR-ESI-MS analysis. The absolute stereochemistry of compound 1 was established by comparing its experimental ECD spectrum with theoretical ECD spectra of all eight possible stereoisomers using TD-DFT calculations, and by evaluating compatibility of calculated 1H chemical shifts with experimental values using DP4 probability method. The cytotoxic effects of some isolated compounds on HepG2 human liver cancer cells and the inhibition of α-glucosidase were evaluated. Compounds 4, 5, and 6 exhibited weak cytotoxicity against HepG2 cells, and showed no inhibitory activity against α-glucosidase (IC50 > 256 µg/ml).
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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