Eggshell Derived Nanohydroxyapatite as a Bone Graft for Intrabony Defects was Evaluated Using (CBCT) - A Randomized Controlled Trial.

IF 0.9 Q4 PHARMACOLOGY & PHARMACY Journal of pharmacy & bioallied sciences Pub Date : 2024-12-01 Epub Date: 2025-01-30 DOI:10.4103/jpbs.jpbs_1041_24
Vishnuvarthan Ganapathy, Anitha Balaji, T S Sampath Kumar, Mohanasatheesh Shanmugam
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Abstract

Aim: The study aims to assess the effectiveness of eggshell-derived nanohydroxyapatite (EnHA) as a bone graft material for treating intrabony defects, using cone-beam computed tomography (CBCT) for evaluation.

Materials and methods: Ten patients were divided into two groups: Group 1: individuals with 2-wall defects, Group 2: those with 3-wall defects. Follow-up appointments at 1-, 3-, and 6-month intervals included assessments of clinical attachment level (CAL), probing depth (PD), and gingival recession (GR). CBCT scans were conducted pre-operative, immediately post-surgery, and at 1-month, 3-month, and 5-month follow-ups.

Results: In both groups, clinical parameters such as CAL, PD, and CBCT measurements reveal significant decreases in CAL and PD values alongside positive trends in CBCT measurements. Additionally, Group 2 exhibited enhancements in periodontal health, suggesting the potential effectiveness of EnHA.

Conclusion: EnHA demonstrates potential as a substitute for bone grafting in intrabony defects, showing favourable trends in both clinical and CBCT evaluations during a 6-month observation period.

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使用CBCT评估蛋壳衍生的纳米羟基磷灰石作为骨内缺损的骨移植物-一项随机对照试验。
目的:利用锥形束计算机断层扫描(CBCT)评估蛋壳源性纳米羟基磷灰石(EnHA)作为骨移植材料治疗骨内缺损的有效性。材料与方法:10例患者分为2组:1组为2壁缺损患者,2组为3壁缺损患者。随访时间间隔为1、3、6个月,包括临床依恋水平(CAL)、探牙深度(PD)和牙龈退行(GR)的评估。术前、术后即刻以及随访1个月、3个月和5个月时进行CBCT扫描。结果:在两组中,CAL、PD和CBCT测量等临床参数显示CAL和PD值显著下降,CBCT测量呈阳性趋势。此外,第2组牙周健康得到改善,表明了EnHA的潜在有效性。结论:在6个月的观察期内,EnHA显示了骨移植作为骨内缺损的替代品的潜力,在临床和CBCT评估中都显示出良好的趋势。
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