Effect of spacer of cationic gemini surfactant on solubility and stability of curcumin

IF 5.3 2区化学 Q2 CHEMISTRY, PHYSICAL Journal of Molecular Liquids Pub Date : 2025-03-08 DOI:10.1016/j.molliq.2025.127345

Jamsheera Anjudikkal , Alok Shukla , Ajmal Koya Pulikkal

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引用次数: 0

Abstract

Curcumin, a potential natural product with a wide range of biological and medicinal properties, limits its application from being used as a promising drug due to its meagre aqueous solubility and stability. The surfactant molecules being amphiphilic in nature, their interaction with curcumin improves the solubility and stability. In this study, curcumin was incorporated with micelles of two gemini surfactants, trimethylene-α,ω-bis(hexadecyldimethylammonium bromide) (G3) and octamethylene-α,ω-bis(hexadecyldimethylammonium bromide) (G8). The critical micelle concentration (cmc) was determined using conductometric and tensiometric studies. The cmc of G8 was found to be higher than the G3. The average hydrodynamic diameter of G3, G8, G3-Curcumin (G3-Cur) and G8-Curcumin (G8-Cur) systems determined using the dynamic light scattering experiment displayed that the incorporation of curcumin into the gemini systems decrease the size of the micelles. The solubility and stability studies revealed that G3 is capable of solubilizing curcumin more efficiently, while the stability of curcumin was substantial in the presence of G8. Fluorescence spectroscopic studies indicated encapsulation of curcumin in the hydrophobic core of G8, whereas, in the case of G3, curcumin is distributed at the micelle-water interface and the hydrophobic core. The DNA binding studies exhibited a superior binding of G8-Cur towards CT-DNA.

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来源期刊

Journal of Molecular Liquids 化学-物理：原子、分子和化学物理

CiteScore

10.30

自引率

16.70%

发文量

2597

审稿时长

78 days

期刊介绍： The journal includes papers in the following areas: – Simple organic liquids and mixtures – Ionic liquids – Surfactant solutions (including micelles and vesicles) and liquid interfaces – Colloidal solutions and nanoparticles – Thermotropic and lyotropic liquid crystals – Ferrofluids – Water, aqueous solutions and other hydrogen-bonded liquids – Lubricants, polymer solutions and melts – Molten metals and salts – Phase transitions and critical phenomena in liquids and confined fluids – Self assembly in complex liquids.– Biomolecules in solution The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include: – Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.) – Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.) – Light scattering (Rayleigh, Brillouin, PCS, etc.) – Dielectric relaxation – X-ray and neutron scattering and diffraction. Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.