Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China.

IF 6.8 3区医学 Q1 PSYCHIATRY General Psychiatry Pub Date : 2025-03-07 eCollection Date: 2025-01-01 DOI:10.1136/gpsych-2024-101736

Tao Wang, Haining He, Yanchen Shi, Ning Su, Minjie Zhu, Feng Yan, Yuanyuan Liu, Juan Li, Muni Tang, Wei Chen, Feng Bao, Huali Wang, Yuping Wang, Ying Liu, Yefeng Yuan, Xiaoyun Zuo, Xulai Zhang, Lijuan Cui, Wenyuan Wu, Chencheng Zhang, Yong Lu, Yiru Fang, Shifu Xiao

{"title":"Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China.","authors":"Tao Wang, Haining He, Yanchen Shi, Ning Su, Minjie Zhu, Feng Yan, Yuanyuan Liu, Juan Li, Muni Tang, Wei Chen, Feng Bao, Huali Wang, Yuping Wang, Ying Liu, Yefeng Yuan, Xiaoyun Zuo, Xulai Zhang, Lijuan Cui, Wenyuan Wu, Chencheng Zhang, Yong Lu, Yiru Fang, Shifu Xiao","doi":"10.1136/gpsych-2024-101736","DOIUrl":null,"url":null,"abstract":"Background: As the population in China rapidly ages, the prevalence of mild cognitive impairment (MCI) is increasing considerably. However, the causes of MCI vary. The continued lack of understanding of the various subtypes of MCI impedes the implementation of effective measures to reduce the risk of advancing to more severe cognitive diseases.Aims: To estimate the prevalence and incidence rates of two MCI subtypes-amnestic MCI (aMCI) and vascular cognitive impairment without dementia (VCIND)-and to determine modifiable factors for them among older individuals in a multiregional Chinese cohort.Method: This 1-year longitudinal study surveyed a random sample of participants aged≥60 years from a large, community-dwelling cohort in China. Baseline lifestyle data were self-reported, while vascular and comorbid conditions were obtained from medical records and physical examinations. In total, 3514 and 2051 individuals completed the baseline and 1-year follow-up assessments, respectively. Logistic and linear regression analyses were used to identify the modifiable factors for MCI subtypes and predictors of cognitive decline, respectively.Results: Among our participants, aMCI and VCIND demonstrated prevalence of 14.83% and 2.71%, respectively, and annual incidence (per 1000 person-years) of 69.6 and 10.6, respectively. The risk factor for aMCI was age, whereas its protective factors were high education level, tea consumption and physical activity. Moreover, VCIND risk factors were age, hypertension and depression. The presence of endocrine disease, cerebral trauma or hypertension was associated with a faster decline in cognition over 1 year.Conclusions: MCI is a serious health problem in China that will only worsen as the population ages if no widespread interventions are implemented. Preventive strategies that promote brain activity and support healthy lifestyle choices are required. We identified modifiable factors for MCI in older individuals. The easy-to-adopt solutions such as tea consumption and physical activity can aid in preventing MCI.Trial registration number: NCT03672448.","PeriodicalId":12549,"journal":{"name":"General Psychiatry","volume":"38 2","pages":"e101736"},"PeriodicalIF":6.8000,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891523/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"General Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/gpsych-2024-101736","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: As the population in China rapidly ages, the prevalence of mild cognitive impairment (MCI) is increasing considerably. However, the causes of MCI vary. The continued lack of understanding of the various subtypes of MCI impedes the implementation of effective measures to reduce the risk of advancing to more severe cognitive diseases.

Aims: To estimate the prevalence and incidence rates of two MCI subtypes-amnestic MCI (aMCI) and vascular cognitive impairment without dementia (VCIND)-and to determine modifiable factors for them among older individuals in a multiregional Chinese cohort.

Method: This 1-year longitudinal study surveyed a random sample of participants aged≥60 years from a large, community-dwelling cohort in China. Baseline lifestyle data were self-reported, while vascular and comorbid conditions were obtained from medical records and physical examinations. In total, 3514 and 2051 individuals completed the baseline and 1-year follow-up assessments, respectively. Logistic and linear regression analyses were used to identify the modifiable factors for MCI subtypes and predictors of cognitive decline, respectively.

Results: Among our participants, aMCI and VCIND demonstrated prevalence of 14.83% and 2.71%, respectively, and annual incidence (per 1000 person-years) of 69.6 and 10.6, respectively. The risk factor for aMCI was age, whereas its protective factors were high education level, tea consumption and physical activity. Moreover, VCIND risk factors were age, hypertension and depression. The presence of endocrine disease, cerebral trauma or hypertension was associated with a faster decline in cognition over 1 year.

Conclusions: MCI is a serious health problem in China that will only worsen as the population ages if no widespread interventions are implemented. Preventive strategies that promote brain activity and support healthy lifestyle choices are required. We identified modifiable factors for MCI in older individuals. The easy-to-adopt solutions such as tea consumption and physical activity can aid in preventing MCI.

Trial registration number: NCT03672448.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

中国轻度认知障碍亚型的患病率、发病率和可改变因素：来自中国纵向老龄化研究的结果

背景：随着中国人口的快速老龄化，轻度认知障碍（MCI）的患病率正在显著增加。然而，MCI的病因各不相同。对轻度认知障碍各种亚型的持续缺乏了解阻碍了有效措施的实施，以降低发展为更严重的认知疾病的风险。目的：估计两种MCI亚型——遗忘性MCI （aMCI）和血管性认知障碍无痴呆（VCIND）的患病率和发病率，并确定在中国多地区队列老年人中可改变的因素。方法：这项为期1年的纵向研究随机调查了来自中国一个大型社区居住队列的年龄≥60岁的参与者。基线生活方式数据是自我报告的，而血管和合并症的情况是从医疗记录和体检中获得的。总共有3514人和2051人分别完成了基线和1年随访评估。分别使用逻辑回归和线性回归分析来确定MCI亚型的可修改因素和认知能力下降的预测因素。结果：在我们的参与者中，aMCI和VCIND的患病率分别为14.83%和2.71%，年发病率（每1000人年）分别为69.6和10.6。年龄是aMCI的危险因素，高学历、饮茶和体育锻炼是aMCI的保护因素。此外，年龄、高血压和抑郁是vind的危险因素。内分泌疾病、脑外伤或高血压的存在与1年内认知能力下降更快有关。结论：MCI在中国是一个严重的健康问题，如果不实施广泛的干预措施，随着人口老龄化，MCI只会恶化。促进大脑活动和支持健康生活方式选择的预防策略是必要的。我们确定了老年人轻度认知障碍的可改变因素。易于采用的解决方案，如喝茶和体育活动，可以帮助预防轻度认知障碍。试验注册号：NCT03672448。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

General Psychiatry 医学-精神病学

CiteScore

21.90

自引率

2.50%

发文量

848

期刊介绍： General Psychiatry (GPSYCH), an open-access journal established in 1959, has been a pioneer in disseminating leading psychiatry research. Addressing a global audience of psychiatrists and mental health professionals, the journal covers diverse topics and publishes original research, systematic reviews, meta-analyses, forums on topical issues, case reports, research methods in psychiatry, and a distinctive section on 'Biostatistics in Psychiatry'. The scope includes original articles on basic research, clinical research, community-based studies, and ecological studies, encompassing a broad spectrum of psychiatric interests.