{"title":"Development of polymer monolith-MOF hybrid via surface functionalization for bioanalytical sciences.","authors":"Kinza Ali, Iqra Munawar, Sara Manan, Fatima Nawazish, Batool Fatima, Fahmida Jabeen, Adeela Saeed","doi":"10.1007/s00216-025-05822-2","DOIUrl":null,"url":null,"abstract":"<p><p>Monoliths are versatile materials with diverse applications, and their performance can be enhanced through modifications, including the use of metal-organic frameworks (MOFs). Modified monoliths improve separation and analytical processes in various fields, with different modification methods offering distinct benefits and challenges. Directly adding MOF crystals to the polymerization mixture is straightforward and time effective, but it often results in poor dispersion and compositional heterogeneity, which compromises consistency and reproducibility, particularly in bioanalytical applications. Although layer-by-layer (LbL) development or post-synthesis functionalization provides greater control over surface coverage and layer thickness, improving selectivity, it is challenging and complicated, making it less appropriate for scalable or high-throughput applications. Despite these challenges, MOFs' capabilities are enhanced by their incorporation into monolithic structures, which provide better performance, efficiency, and selectivity. These hybrid materials have a lot of potential for use in pharmaceutical development, environmental monitoring, and biomolecule enrichment. However, concerns like material heterogeneity, reproducibility, and scalability limit their practical application in bioanalysis.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical and Bioanalytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s00216-025-05822-2","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
Monoliths are versatile materials with diverse applications, and their performance can be enhanced through modifications, including the use of metal-organic frameworks (MOFs). Modified monoliths improve separation and analytical processes in various fields, with different modification methods offering distinct benefits and challenges. Directly adding MOF crystals to the polymerization mixture is straightforward and time effective, but it often results in poor dispersion and compositional heterogeneity, which compromises consistency and reproducibility, particularly in bioanalytical applications. Although layer-by-layer (LbL) development or post-synthesis functionalization provides greater control over surface coverage and layer thickness, improving selectivity, it is challenging and complicated, making it less appropriate for scalable or high-throughput applications. Despite these challenges, MOFs' capabilities are enhanced by their incorporation into monolithic structures, which provide better performance, efficiency, and selectivity. These hybrid materials have a lot of potential for use in pharmaceutical development, environmental monitoring, and biomolecule enrichment. However, concerns like material heterogeneity, reproducibility, and scalability limit their practical application in bioanalysis.
期刊介绍:
Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.