Development of polymer monolith-MOF hybrid via surface functionalization for bioanalytical sciences.

IF 3.8 2区 化学 Q1 BIOCHEMICAL RESEARCH METHODS Analytical and Bioanalytical Chemistry Pub Date : 2025-03-12 DOI:10.1007/s00216-025-05822-2
Kinza Ali, Iqra Munawar, Sara Manan, Fatima Nawazish, Batool Fatima, Fahmida Jabeen, Adeela Saeed
{"title":"Development of polymer monolith-MOF hybrid via surface functionalization for bioanalytical sciences.","authors":"Kinza Ali, Iqra Munawar, Sara Manan, Fatima Nawazish, Batool Fatima, Fahmida Jabeen, Adeela Saeed","doi":"10.1007/s00216-025-05822-2","DOIUrl":null,"url":null,"abstract":"<p><p>Monoliths are versatile materials with diverse applications, and their performance can be enhanced through modifications, including the use of metal-organic frameworks (MOFs). Modified monoliths improve separation and analytical processes in various fields, with different modification methods offering distinct benefits and challenges. Directly adding MOF crystals to the polymerization mixture is straightforward and time effective, but it often results in poor dispersion and compositional heterogeneity, which compromises consistency and reproducibility, particularly in bioanalytical applications. Although layer-by-layer (LbL) development or post-synthesis functionalization provides greater control over surface coverage and layer thickness, improving selectivity, it is challenging and complicated, making it less appropriate for scalable or high-throughput applications. Despite these challenges, MOFs' capabilities are enhanced by their incorporation into monolithic structures, which provide better performance, efficiency, and selectivity. These hybrid materials have a lot of potential for use in pharmaceutical development, environmental monitoring, and biomolecule enrichment. However, concerns like material heterogeneity, reproducibility, and scalability limit their practical application in bioanalysis.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Analytical and Bioanalytical Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s00216-025-05822-2","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0

Abstract

Monoliths are versatile materials with diverse applications, and their performance can be enhanced through modifications, including the use of metal-organic frameworks (MOFs). Modified monoliths improve separation and analytical processes in various fields, with different modification methods offering distinct benefits and challenges. Directly adding MOF crystals to the polymerization mixture is straightforward and time effective, but it often results in poor dispersion and compositional heterogeneity, which compromises consistency and reproducibility, particularly in bioanalytical applications. Although layer-by-layer (LbL) development or post-synthesis functionalization provides greater control over surface coverage and layer thickness, improving selectivity, it is challenging and complicated, making it less appropriate for scalable or high-throughput applications. Despite these challenges, MOFs' capabilities are enhanced by their incorporation into monolithic structures, which provide better performance, efficiency, and selectivity. These hybrid materials have a lot of potential for use in pharmaceutical development, environmental monitoring, and biomolecule enrichment. However, concerns like material heterogeneity, reproducibility, and scalability limit their practical application in bioanalysis.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
8.00
自引率
4.70%
发文量
638
审稿时长
2.1 months
期刊介绍: Analytical and Bioanalytical Chemistry’s mission is the rapid publication of excellent and high-impact research articles on fundamental and applied topics of analytical and bioanalytical measurement science. Its scope is broad, and ranges from novel measurement platforms and their characterization to multidisciplinary approaches that effectively address important scientific problems. The Editors encourage submissions presenting innovative analytical research in concept, instrumentation, methods, and/or applications, including: mass spectrometry, spectroscopy, and electroanalysis; advanced separations; analytical strategies in “-omics” and imaging, bioanalysis, and sampling; miniaturized devices, medical diagnostics, sensors; analytical characterization of nano- and biomaterials; chemometrics and advanced data analysis.
期刊最新文献
Isolation of bovine milk-derived extracellular vesicles via a capillary-channeled polymer (C-CP) fiber stationary phase. Assessment of in-house reference materials for multi-pesticide residue analysis in three food matrices by LC-MS/MS: development, homogeneity, and stability. Development of polymer monolith-MOF hybrid via surface functionalization for bioanalytical sciences. Optimizing solvent extraction methods for activated carbon-based passive samplers in atmospheric volatile organic compound analysis: minimizing analytical interferences from pretreatment solvents and ensuring quantitative reliability. Preparation and characterization of a certified reference material of toxic elements in cannabis leaves.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1