Retraction Note: Morin attenuates ferroptosis via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate diabetic cardiomyopathy in vivo.

Qingmei Wang, Xuanguo Zhang, Li Xi
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Abstract

The article Morin Attenuates Ferroptosis via Activation of the SIRT1/p53/SLC7A11 Signaling Pathway to Alleviate Diabetic Cardiomyopathy In Vivo, by Qingmei Wang, Xuanguo Zhang and Li Xi, published online on March 12, 2025 has been retracted by the Editor-in-Chief and the Publisher. Following an internal investigation by the Publisher, irregularities with respect to the submission and peer review were found. Consequently, the Editor-in-Chief therefore no longer has confidence in the results and conclusions presented in the article. The authors do not agree with this retraction.

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在体内,马桑素通过激活SIRT1/p53/SLC7A11信号通路减轻铁下垂,从而减轻糖尿病性心肌病。
糖尿病性心肌病(DCM)是糖尿病患者的严重并发症,目前仍缺乏适当的治疗。上睑下垂最近被强调为DCM发展的主要贡献者。因此,本研究旨在评估桑辣素(一种众所周知的植物化学物质)对DCM的影响。为此,采用链脲佐菌素(STZ)诱导Wistar大鼠DCM。给动物口服25、50、100 mg/kg桑肽60 d后,测定心脏组织中SIRT1 (SIRT1)、p53、溶质载体家族7成员11 (SLC7A11)和谷胱甘肽过氧化物酶4 (GPX4)的基因和蛋白水平。此外,测定心脏组织中的氧化还原状态(GSH、SOD、CAT和MDA)和炎症标志物(IL-6、IL-1和TNF-),并评估糖脂谱、铁谱和心脏标志物(肌钙蛋白T和CK-MB)的水平。研究结果表明,给药马桑素恢复糖脂和铁谱,改善高血压和心脏肥厚,抑制炎症反应(p值
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