Sarah B Barkley, Talena Day, Matthew D Lerner, Brady D Nelson
{"title":"Autism, Personality Pathology, and the Neural Response to Rewards.","authors":"Sarah B Barkley, Talena Day, Matthew D Lerner, Brady D Nelson","doi":"10.1007/s10803-025-06789-w","DOIUrl":null,"url":null,"abstract":"<p><p>The autism social motivation hypothesis suggests that diminished reward value of social stimuli contributes to deficits in social motivation. Research indicates that autistic individuals show decreased neural responding to both social and non-social reward, suggesting domain-general reward system differences. However, autism is heterogenous with extensive co-occurring psychopathology, and the autism phenotype may not be the best way to understand its relationship with neural reward response. Autism has been associated with normative and pathological personality domains that may better represent the heterogeneity and comorbidity of autism. The present study examined associations between autism traits, pathological personality, and the neural response to multiple reward types. The sample included 18-33-year-old undergraduates who completed monetary, social, and restricted interests reward tasks while we recorded electroencephalography to measure the reward positivity (RewP), an event-related potential indicator of reward sensitivity. Participants completed self-report measures of autism traits and the pathological personality traits negative emotionality, detachment, and anankastia. Autism traits were not directly related to the RewP but were positively associated with pathological personality dimensions. Across all reward tasks, negative emotionality was related to a larger RewP while detachment and anankastia were related to a smaller RewP. All three pathological personality dimensions mediated the relationship between autism traits and the RewP. The present study suggests that autism and neural reward response is at least partially mediated by comorbid psychopathology. Moreover, the results are inconsistent with the social motivation hypothesis and instead suggest that autism is linked to domain-general neural response to rewards.</p>","PeriodicalId":15148,"journal":{"name":"Journal of Autism and Developmental Disorders","volume":" ","pages":""},"PeriodicalIF":3.2000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Autism and Developmental Disorders","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1007/s10803-025-06789-w","RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHOLOGY, DEVELOPMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
The autism social motivation hypothesis suggests that diminished reward value of social stimuli contributes to deficits in social motivation. Research indicates that autistic individuals show decreased neural responding to both social and non-social reward, suggesting domain-general reward system differences. However, autism is heterogenous with extensive co-occurring psychopathology, and the autism phenotype may not be the best way to understand its relationship with neural reward response. Autism has been associated with normative and pathological personality domains that may better represent the heterogeneity and comorbidity of autism. The present study examined associations between autism traits, pathological personality, and the neural response to multiple reward types. The sample included 18-33-year-old undergraduates who completed monetary, social, and restricted interests reward tasks while we recorded electroencephalography to measure the reward positivity (RewP), an event-related potential indicator of reward sensitivity. Participants completed self-report measures of autism traits and the pathological personality traits negative emotionality, detachment, and anankastia. Autism traits were not directly related to the RewP but were positively associated with pathological personality dimensions. Across all reward tasks, negative emotionality was related to a larger RewP while detachment and anankastia were related to a smaller RewP. All three pathological personality dimensions mediated the relationship between autism traits and the RewP. The present study suggests that autism and neural reward response is at least partially mediated by comorbid psychopathology. Moreover, the results are inconsistent with the social motivation hypothesis and instead suggest that autism is linked to domain-general neural response to rewards.
期刊介绍:
The Journal of Autism and Developmental Disorders seeks to advance theoretical and applied research as well as examine and evaluate clinical diagnoses and treatments for autism and related disabilities. JADD encourages research submissions on the causes of ASDs and related disorders, including genetic, immunological, and environmental factors; diagnosis and assessment tools (e.g., for early detection as well as behavioral and communications characteristics); and prevention and treatment options. Sample topics include: Social responsiveness in young children with autism Advances in diagnosing and reporting autism Omega-3 fatty acids to treat autism symptoms Parental and child adherence to behavioral and medical treatments for autism Increasing independent task completion by students with autism spectrum disorder Does laughter differ in children with autism? Predicting ASD diagnosis and social impairment in younger siblings of children with autism The effects of psychotropic and nonpsychotropic medication with adolescents and adults with ASD Increasing independence for individuals with ASDs Group interventions to promote social skills in school-aged children with ASDs Standard diagnostic measures for ASDs Substance abuse in adults with autism Differentiating between ADHD and autism symptoms Social competence and social skills training and interventions for children with ASDs Therapeutic horseback riding and social functioning in children with autism Authors and readers of the Journal of Autism and Developmental Disorders include sch olars, researchers, professionals, policy makers, and graduate students from a broad range of cross-disciplines, including developmental, clinical child, and school psychology; pediatrics; psychiatry; education; social work and counseling; speech, communication, and physical therapy; medicine and neuroscience; and public health.