Interoception and mental health in middle-aged and elderly adults: A systematic review and meta-analysis

IF 7.5 1区医学 Q1 BEHAVIORAL SCIENCES Neuroscience and Biobehavioral Reviews Pub Date : 2025-03-12 DOI:10.1016/j.neubiorev.2025.106104

Meiling Qi, Xiaona Shen, Yue Zeng, Xiaohe Lin, Muhammad Suliman, Ping Li

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Abstract

Background

Recent studies have identified interoceptive dysfunction as a critical biomarker for emotional disorders. It is well-established that aging correlates with a deterioration in interoceptive capabilities, which consequently affects emotional processing dynamics.

Methods

This study performed a systematic review and meta-analysis to evaluate the associations between interoceptive variants and mental health in middle-aged and elderly adults. Three English databases, including PubMed, Web of Science, and Medline (via EBSCO), were electronically searched from inception through December 2023. The study quality and meta-analysis were performed using the MMAT and RevMan 5.4 software.

Results

A total of 21 studies were included in this systematic review, and data from 14 studies were used in the meta-analysis. Favorable associations were seen between interoception and depression (pooled r = -0.11 (95CI%: −0.19 to −0.03), z = 2.72, p = 0.006, I²= 0 %), alexithymia (pooled r = -0.25 (95CI%: −0.35 to −0.16), z = 4.84, p < 0.001, I²= 31 %), and emotion regulation (pooled r = 0.30 (95CI%: 0.18–0.41), z = 4.63, p < 0.001, I²= 33 %). Interoception showed no significant correlation with other mental health outcomes.

Conclusion

This systematic review and meta-analysis underscore the importance of interoception in understanding the underlying neural mechanisms of depression, alexithymia, and emotion regulation in middle-aged and older adults. Interoceptive training could also potentially serve as an effective strategy for promoting mental health within this demographic.

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来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.