Interoception and mental health in middle-aged and elderly adults: A systematic review and meta-analysis

IF 7.9 1区医学 Q1 BEHAVIORAL SCIENCES Neuroscience and Biobehavioral Reviews Pub Date : 2025-05-01 Epub Date: 2025-03-12 DOI:10.1016/j.neubiorev.2025.106104

Meiling Qi, Xiaona Shen, Yue Zeng, Xiaohe Lin, Muhammad Suliman, Ping Li

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Abstract

Background

Recent studies have identified interoceptive dysfunction as a critical biomarker for emotional disorders. It is well-established that aging correlates with a deterioration in interoceptive capabilities, which consequently affects emotional processing dynamics.

Methods

This study performed a systematic review and meta-analysis to evaluate the associations between interoceptive variants and mental health in middle-aged and elderly adults. Three English databases, including PubMed, Web of Science, and Medline (via EBSCO), were electronically searched from inception through December 2023. The study quality and meta-analysis were performed using the MMAT and RevMan 5.4 software.

Results

A total of 21 studies were included in this systematic review, and data from 14 studies were used in the meta-analysis. Favorable associations were seen between interoception and depression (pooled r = -0.11 (95CI%: −0.19 to −0.03), z = 2.72, p = 0.006, I²= 0 %), alexithymia (pooled r = -0.25 (95CI%: −0.35 to −0.16), z = 4.84, p < 0.001, I²= 31 %), and emotion regulation (pooled r = 0.30 (95CI%: 0.18–0.41), z = 4.63, p < 0.001, I²= 33 %). Interoception showed no significant correlation with other mental health outcomes.

Conclusion

This systematic review and meta-analysis underscore the importance of interoception in understanding the underlying neural mechanisms of depression, alexithymia, and emotion regulation in middle-aged and older adults. Interoceptive training could also potentially serve as an effective strategy for promoting mental health within this demographic.

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中老年人的内感受与心理健康：系统回顾和荟萃分析。

背景：最近的研究已经确定内感受功能障碍是情绪障碍的一个重要生物标志物。衰老与内感受能力的退化有关，从而影响情绪处理动态。方法：本研究通过系统回顾和荟萃分析来评估中老年人内感受变异与心理健康之间的关系。三个英文数据库，包括PubMed， Web of Science和Medline（通过EBSCO），从成立到2023年12月进行了电子检索。采用MMAT和RevMan 5.4软件进行研究质量和meta分析。结果：本系统综述共纳入21项研究，荟萃分析采用14项研究的数据。内感受与抑郁（合并r=-0.11 (95CI%: -0.19至-0.03),z=2.72, p=0.006, I2=0%）、述情障碍（合并r=-0.25 (95CI%: -0.35至-0.16),z=4.84, p2=31%）和情绪调节（合并r=0.30 (95CI%: 0.18至0.41),z=4.63, p2=33%）之间存在良好的关联。内感受与其他心理健康结果无显著相关性。结论：本系统综述和荟萃分析强调了内感受在理解中老年人抑郁、述情障碍和情绪调节的潜在神经机制中的重要性。内感受性训练也可能成为促进这一人群心理健康的有效策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neuroscience and Biobehavioral Reviews 医学-行为科学

CiteScore

14.20

自引率

3.70%

发文量

466

审稿时长

6 months

期刊介绍： The official journal of the International Behavioral Neuroscience Society publishes original and significant review articles that explore the intersection between neuroscience and the study of psychological processes and behavior. The journal also welcomes articles that primarily focus on psychological processes and behavior, as long as they have relevance to one or more areas of neuroscience.

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