Advances in rhabdomyolysis: A review of pathogenesis, diagnosis, and treatment.

IF 1.8 4区 医学 Q2 ORTHOPEDICS Chinese Journal of Traumatology Pub Date : 2025-02-27 DOI:10.1016/j.cjtee.2024.10.005
Bo-Fan Yang, Duo Li, Chun-Li Liu, Yu Luo, Jie Shi, Xiao-Qin Guo, Hao-Jun Fan, Qi Lv
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引用次数: 0

Abstract

Rhabdomyolysis (RM) is a multifactorial clinical syndrome characterized by the disintegration and necrosis of muscle tissue, leading to the release of cellular contents into the circulation. One of the most severe complications of RM is acute kidney injury, with a mortality rate of 20%-50%. Early and timely diagnosis is the key to improving the prognosis of patients with RM. The etiology of RM is complex and associated with various traumas, drugs, medications, and hereditary diseases, and the clinical symptoms are nonspecific. Therefore, its diagnosis highly relies on the doctor's experience and the level of medical equipment. However, RM often occurs in situations with limited medical resources, such as natural disasters, battlefields, and large-scale traffic accidents. In these scenarios, the varying levels of expertise among rescue personnel can lead to delays in diagnosis and treatment, thereby increasing the risk of mortality. This article provides a comprehensive review of the etiology, pathogenesis, complications, diagnostic, and treatment methods of RM. It also aims to offer new perspectives on the diagnosis and prognosis of RM by integrating machine learning and artificial intelligence. It is believed that this article can help pre-hospital rescuers and in-hospital doctors have a comprehensive understanding of RM to improve the patients' outcomes and overcome the challenges.

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来源期刊
CiteScore
3.80
自引率
4.80%
发文量
1707
审稿时长
28 weeks
期刊介绍: Chinese Journal of Traumatology (CJT, ISSN 1008-1275) was launched in 1998 and is a peer-reviewed English journal authorized by Chinese Association of Trauma, Chinese Medical Association. It is multidisciplinary and designed to provide the most current and relevant information for both the clinical and basic research in the field of traumatic medicine. CJT primarily publishes expert forums, original papers, case reports and so on. Topics cover trauma system and management, surgical procedures, acute care, rehabilitation, post-traumatic complications, translational medicine, traffic medicine and other related areas. The journal especially emphasizes clinical application, technique, surgical video, guideline, recommendations for more effective surgical approaches.
期刊最新文献
Dorsal metacarpal artery perforator flaps for traumatic soft tissue defect of finger: A prospective anatomical and clinical study. Advances in rhabdomyolysis: A review of pathogenesis, diagnosis, and treatment. Comparison of hook plates vs. locking plates for Neer type IIB fractures of lateral end clavicle: A systematic review. Construction and preliminary trial test of a decision-making app for pre-hospital damage control resuscitation. Celebrating the life of Professor Wang Zhengguo.
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