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Efficacy and safety of conventional biplanar and triangulation method for sacroiliac screw placement in the treatment of unstable posterior pelvic ring fractures: A real-world retrospective cohort study.
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-15 DOI: 10.1016/j.cjtee.2024.07.015
Yu-Bo Zheng, Xing Han, Xin Zhao, Xi-Guang Sang

Purpose: The fixation method commonly employed worldwide for treating unstable fractures of the posterior pelvic ring is the percutaneous iliosacral screw technique. However, prolonged operation time and frequent fluoroscopies result in surgical risks. This study aimed to investigate whether a new triangulation method could reduce operative and fluoroscopy times and increase the accuracy of screw placement.

Methods: This study is a real-world retrospective cohort analysis that examined a patient cohort who underwent percutaneous iliosacral screw fixation between January 1, 2019 and December 31, 2022. Inclusion criteria were patients (1) diagnosed with posterior pelvic ring instability who underwent pelvic fracture closed reduction and percutaneous S1 transverse-penetrating iliosacral screw placement and (2) aged >18 years. Exclusion criteria were: (1) combined proximal femoral fractures, (2) severe soft tissue injury in the surgical area, (3) incomplete imaging data, and (4) declining to provide written informed consent by the patient. The patients were divided into 2 groups according to the screw insertion method: conventional and triangulation methods. Screw placement and fluoroscopy times recorded by the C-arm were compared between the 2 methods. The accuracy of screw placement was evaluated by Smith grading on postoperative CT. Normality tests were conducted to assess the distribution of the quantitative variables and the Chi-square test was used to compare the qualitative variables.

Results: The study included a total of 94 patients diagnosed with posterior pelvic ring instability, who underwent percutaneous iliosacral screw placement. The patients were divided into 2 groups: 46 patients treated with the conventional surgical method and 48 patients received the triangulation method. The operation time (61.13±9.69 vs. 35.77±6.27) min and fluoroscopy frequency times (52.15±9.29 vs 24.40±4.04) of the triangulation method were significantly reduced (p<0.001).

Conclusions: The use of a triangular positioning technique for the surface positioning of percutaneous iliosacral screws could reduce the operative time and fluoroscopy frequency. And screw placement accuracy using this new method was comparable to that using other conventional methods.

目的:经皮髂骶螺钉技术是全世界治疗骨盆后环不稳定骨折的常用固定方法。然而,手术时间长和频繁的透视检查会导致手术风险。本研究旨在探讨一种新的三角定位方法能否缩短手术和透视时间,并提高螺钉置入的准确性:本研究是一项真实世界的回顾性队列分析,研究对象是在 2019 年 1 月 1 日至 2022 年 12 月 31 日期间接受经皮髂骶螺钉固定术的患者队列。纳入标准为:(1) 诊断为后骨盆环不稳,接受骨盆骨折闭合复位术和经皮 S1 横穿髂骶螺钉置入术的患者;(2) 年龄大于 18 岁。排除标准为(1)合并股骨近端骨折;(2)手术区域软组织严重损伤;(3)影像学资料不完整;(4)患者拒绝提供书面知情同意书。根据螺钉植入方法将患者分为两组:传统法和三角法。比较了两种方法的螺钉置入和 C 臂记录的透视时间。术后 CT 上的 Smith 分级评估了螺钉置入的准确性。对定量变量的分布进行了正态性检验,对定性变量进行了卡方检验:研究共纳入了94名确诊为骨盆后环不稳定的患者,他们都接受了经皮髂骶螺钉置入术。患者分为两组:46 名患者采用传统手术方法治疗,48 名患者采用三角定位法治疗。三角定位法的手术时间(61.13±9.69 vs. 35.77±6.27)分钟和透视次数(52.15±9.29 vs. 24.40±4.04)显著减少(p结论:使用三角定位技术进行经皮髂胫螺钉表面定位可减少手术时间和透视次数。使用这种新方法的螺钉置放精确度与使用其他传统方法的置放精确度相当。
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引用次数: 0
How does attention deficit/hyperactivity disorder affect driving behavior components? Baseline findings from Persian traffic cohort. 注意缺陷/多动障碍如何影响驾驶行为成分?波斯交通队列的基线结果。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-03 DOI: 10.1016/j.cjtee.2024.09.008
Sepideh Harzand-Jadidi, Mina Golestani, Leila Vahedi, Mahdi Rezaei, Mostafa Farahbakhsh, Homayoun Sadeghi-Bazargani

Purpose: Attention-deficit/hyperactivity disorder (ADHD) increases the risk of road traffic injuries through various mechanisms including higher risky driving behaviors. Therefore, drivers with ADHD are shown to be more prone to road traffic injuries. This study was conducted in a community-based sample of drivers to determine how ADHD affects driving behavior components.

Methods: At the cross-sectional phase of a national population-based cohort, a representative sample of 1769 drivers were enrolled. Manchester driving behavior questionnaire and Conners' adult ADHD rating scales were used to assess driving behavior and ADHD symptom scores, respectively. Data were analyzed using Stata version 17. Multiple linear regression was used to investigate the association of driving behavior with ADHD while adjusting for the potential confounding role of age, sex, marital status, educational level, driving history, etc. RESULTS: According to the results, the normalized driving behavior score of drivers with ADHD was 4.64 points higher than drivers without ADHD. Having an academic compared to school education, increased the driving behavior score by 1.73 points. The normalized driving behavior score of drivers under 18 years of age was 6.27 points higher than drivers aged 31 - 45 years. The score of the aggressive violation subscale of drivers with ADHD was 7.33 points higher than drivers without ADHD compared to an increment of a range of 4.50-4.82 points for other driving subscales. The score of the ordinary violation subscale of female drivers was 2.23 points lower than that of male drivers. No significant relationship was found between sex and other subscales of driving.

Conclusion: Drivers with ADHD who are in adolescence or early adulthood exhibit more dangerous and aggressive driving behaviors than those who are older. Implementing training interventions to increase awareness of drivers with ADHD, their families, and psychologists regarding the effects of ADHD on driving is an essential step in preventing motor vehicle crashes among drivers with ADHD.

目的:注意缺陷/多动障碍(ADHD)通过包括高风险驾驶行为在内的多种机制增加道路交通伤害的风险。因此,患有多动症的司机更容易发生道路交通伤害。本研究在以社区为基础的司机样本中进行,以确定ADHD如何影响驾驶行为的组成部分。方法:在以全国人口为基础的队列的横截面阶段,纳入了1769名司机的代表性样本。采用Manchester驾驶行为问卷和Conners成人ADHD评定量表分别评定驾驶行为和ADHD症状得分。使用Stata version 17分析数据。采用多元线性回归研究驾驶行为与ADHD的关系,并对年龄、性别、婚姻状况、教育程度、驾驶史等因素的潜在混杂作用进行校正。结果:结果显示,ADHD驾驶员的标准化驾驶行为得分比非ADHD驾驶员高4.64分。与学校教育相比,拥有学历的人的驾驶行为得分提高了1.73分。18岁以下驾驶员驾驶行为标准化得分比31 - 45岁驾驶员高6.27分。ADHD司机的攻击性违规量表得分比非ADHD司机高7.33分,而其他驾驶量表的增量范围为4.50-4.82分。女性司机的普通违规子量表得分比男性司机低2.23分。性别与驾驶的其他分量表之间没有显著的关系。结论:青少年或成年早期的ADHD驾驶员比老年ADHD驾驶员表现出更危险和更具攻击性的驾驶行为。实施培训干预措施,提高ADHD司机、他们的家人和心理学家对ADHD对驾驶影响的认识,是预防ADHD司机发生车祸的重要一步。
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引用次数: 0
Multiomics analysis elucidated the role of inflammatory response and bile acid metabolism disturbance in electric shock-induced liver injury in mice. 多组学分析阐明了炎症反应和胆汁酸代谢紊乱在小鼠电刺激肝损伤中的作用。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-03 DOI: 10.1016/j.cjtee.2024.08.011
Wenjuan Zhang, Luncai Yin, Hui Wang, Ce Long, Jin Liu, Ping Deng, Yang Yue, Jingdian Li, Mindi He, Yonghui Lu, Yan Luo, Siyu Chen, Jiawen Tao, Li Tian, Jia Xie, Mengyan Chen, Zhengping Yu, Zhou Zhou, Peng Gao, Huifeng Pi

Purpose: Organ damage caused by electric shock has attracted great attention. Some animal investigations and clinical cases have suggested that electric shock can induce liver injury. This study aimed to investigate the potential mechanism of liver injury induced by electric shock.

Methods: Healthy male C57BL/6J mice aged 6-8 weeks were romandly divided into two groups: control group and electric shock group. Mice in the electric shock group were shocked on the top of the skull with an electric baton (20 kV) for 5 sec, while mice in the control group were exposed to only the acoustic and light stimulation produced by the electric baton. The effect of electric shock on liver function was evaluated by histological and biochemical analysis, and a metabolomics and transcriptomics study was performed to investigate how electric shock might induce liver damage. All data of this study were analyzed using a two-tailed unpaired Student's t-test in SPSS 22.0 Statistical Package.

Results: The electric shock group had significantly higher serum aspartate aminotransferase and alanine aminotransferase levels than the control group (p < 0.001), and the shock notably caused cytoplasmic swelling and vacuolization, mild inflammatory cell (mainly macrophages and monocytes) infiltration and acute focal necrosis in hepatocytes (p < 0.001). A total of 47 differential metabolites and 249 differentially expressed genes (DEGs) were detected using metabolomic and transcriptomic analyses. These differential metabolites were significantly enriched in primary bile acid biosynthesis (p < 0.05). Gene ontology functional analysis of the DEGs revealed that electric shock disturbed a key biological process involved in the inflammatory response in the mouse liver, and a significant number of DEGs were enriched in Kyoto Encyclopedia of Genes and Genomes-identified pathways related to inflammation, such as the interleukin-17, tumor necrosis factor and mitogen-activated protein kinase signalling pathway. Transcriptomic and metabolomic analyses revealed that bile acid metabolism disturbance including up-regulation of the taurochenodesoxycholic acid, chenodeoxycholic acid and taurocholic acid, and down-regulation of chenodeoxycholic acid clycine conjugate may contribute to the electric shock-induced inflammatory response.

Conclusion: Electric shock can induce liver inflammatory injury through the interleukin-17, tumor necrosis factor, and mitogen-activated protein kinase signaling pathway, and the bile acid metabolism disturbance including up-regulation of the taurochenodesoxycholic acid, chenodeoxycholic acid and taurocholic acid, and down-regulation of chenodeoxycholic acid clycine conjugate may contribute to inflammatory liver injury following electric shock.

目的:电击引起的器官损伤已引起广泛关注。一些动物实验和临床病例表明,电击可引起肝损伤。本研究旨在探讨电致肝损伤的潜在机制。方法:将6 ~ 8周龄健康雄性C57BL/6J小鼠随机分为对照组和电击组。电击组用20 kV的电棒对小鼠颅骨顶部进行5秒的电击,而对照组小鼠仅接受电棒产生的声和光刺激。通过组织学和生化分析来评估电击对肝功能的影响,并进行代谢组学和转录组学研究来研究电击如何引起肝损伤。本研究的所有数据均采用SPSS 22.0统计软件包中的双尾非配对Student's t检验进行分析。结果:电击组患者血清天冬氨酸转氨酶和丙氨酸转氨酶水平明显高于对照组(p)。触电可通过白细胞介素-17、肿瘤坏死因子、丝裂原活化蛋白激酶信号通路诱导肝脏炎性损伤,其中牛磺酸、鹅去氧胆酸、牛去氧胆酸上调、鹅去氧胆酸疫苗偶联物下调等胆汁酸代谢紊乱可导致触电后炎性肝损伤。
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引用次数: 0
Research progress of tourniquets and their application in the Russia-Ukraine Conflict. 止血带的研究进展及其在俄乌冲突中的应用。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-09-13 DOI: 10.1016/j.cjtee.2024.07.010
Shaojie Nie, Kangkang Zhi, Lefeng Qu

Against the backdrop of the Russia-Ukraine Conflict in 2022, this article reviews the characteristics of traumatic hemorrhage in modern warfare spanning the past century. It investigates several types of tourniquets used by the Russian and Ukrainian armed forces, including limb tourniquets and junctional tourniquets recommended by the Committee on Tactical Combat Casualty Care, tourniquets employed by the Armed Forces of the Russian Federation, and those used by the Armed Forces of Ukraine in the Russia-Ukraine Conflict. The analysis is conducted from perspectives, including the structure, usage methods, and limitations of different tourniquets. Additionally, the article synthesizes the research progress on tourniquets from 3 angles: battlefield adaptability, the impact of tourniquet application methods on patient outcomes, and training in tourniquet usage, offering insights from our team's perspective.

本文以 2022 年俄乌冲突为背景,回顾了上个世纪现代战争中创伤性出血的特点。文章研究了俄罗斯和乌克兰武装部队使用的几种止血带,包括战术战斗伤员救护委员会推荐的肢体止血带和连接止血带、俄罗斯联邦武装部队使用的止血带以及乌克兰武装部队在俄乌冲突中使用的止血带。文章从不同止血带的结构、使用方法和局限性等角度进行了分析。此外,文章还从战场适应性、止血带使用方法对患者预后的影响和止血带使用培训三个角度综合了止血带的研究进展,提出了我们团队的见解。
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引用次数: 0
A novel arterial coupler with non-return snap-fit connection approach optimized arterial end-to-end anastomotic technique: An experimental study. 新型动脉耦合器与非回流卡入式连接方法优化了动脉端到端吻合技术:实验研究。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-09-17 DOI: 10.1016/j.cjtee.2024.09.006
Hong-Bo Guo, Mo-Fei Wang, Ren-Qi Yin, Kang-Kang Zhi
<p><strong>Purpose: </strong>Hand-sewn anastomosis as the gold standard of vascular anastomosis cannot fully meet the requirements of vascular anastomosis in speed and quality. Various vascular couplers have been developed to ameliorate this situation. Most of them are mainly used for venous anastomosis rather than arterial anastomosis. Although it is generally acknowledged that in almost all operations involving vascular reconstruction, it is the arteries that need to be anastomosed faster and more accurately and not the veins. A dedicated device is needed for creating arterial anastomosis in an easy, timesaving, less damaging but reliable procedure. Therefore, we plan to develop a novel arterial coupler device and test pre-clinical safety and effectiveness.</p><p><strong>Methods: </strong>In this cohort study, the rationality of this novel arterial coupler was preliminarily tested by finite element analysis before it was manufactured. Several factors restrict the use of vascular couplers in arterial anastomosis, such as arterial eversion, fixation, etc. The manufactured arterial couplers underwent in vitro and in vivo experiments. In vitro, isolated arteries of beagles were anastomosed with the assistance of an arterial coupler, and the anastomosed arteries were evaluated through anti-traction tests. In animal experiments, the bilateral femoral arteries of 5 beagles served as a control group. After dissection, the femoral artery on one side was randomly selected to be anastomosed with a quick arterial coupler (QAC) (QAC group), and the femoral artery on the other side was anastomosed by the same person using an end-to-end suture technique with a 6-0 Prolene suture (suture group). The bilateral femoral arteries of 5 beagles were used for coupler-assisted anastomosis and hand-sewn anastomosis in vivo, respectively. Success rate, blood loss, anastomotic time, clamp time, total operation time, and patency rate were recorded. The patency of anastomosed arteries was assessed using vascular Doppler ultrasound, electromagnetic flowmeter, and pathological examination (6 weeks after surgery).</p><p><strong>Results: </strong>As a novel arterial coupler, QAC was successfully designed and manufactured by using poly lactic-co-glycolic acid raw materials and 3-dimensions printing technology. Its rationality was preliminarily tested through finite element analysis and related mechanical analysis methods. The isolated arteries were successfully anastomosed with the assistance of QAC in vitro testing, which showed good anti-traction properties. In animal studies, QAC-assisted arterial anastomosis has superior profiles compared to hand-sewn anastomosis in anastomotic time (7.80 ± 1.41 vs. 16.38 ± 1.04 min), clamp time (8.80 ± 1.41 vs. 14.14 ± 1.57 min), and total operation time (46.64 ± 2.38 vs. 51.96 ± 3.65 min). The results of electromagnetic flowmeter, vascular Doppler ultrasound, and pathological examination showed that QAC-assisted anastomotic arteries were
目的:手工缝合作为血管吻合的金标准,在速度和质量上无法完全满足血管吻合的要求。为了改善这种情况,人们开发了各种血管耦合器。尽管人们普遍认为,在几乎所有涉及血管重建的手术中,需要更快、更准确吻合的是动脉而不是静脉,但它们大多主要用于静脉吻合而不是动脉吻合。因此,我们需要一种专用设备,以简便、省时、损伤小且可靠的方式进行动脉吻合。因此,我们计划开发一种新型动脉耦合器装置,并对其临床前安全性和有效性进行测试:在这项队列研究中,我们在制造这种新型动脉耦合器之前,通过有限元分析对其合理性进行了初步测试。在动脉吻合术中使用血管耦合器受到多种因素的限制,如动脉外翻、固定等。制造出的动脉耦合器经过了体外和体内实验。在体外实验中,在动脉耦合器的辅助下吻合了小猎犬的离体动脉,并通过抗牵引试验对吻合动脉进行了评估。在动物实验中,5 只猎犬的双侧股动脉作为对照组。解剖后,随机选择一侧股动脉用快速动脉耦合器(QAC)进行吻合(QAC 组),另一侧股动脉由同一人使用 6-0 Prolene 缝线进行端对端缝合(缝合组)。5 只猎犬的双侧股动脉分别用于耦合器辅助吻合和体内手缝吻合。记录了吻合成功率、失血量、吻合时间、钳夹时间、总手术时间和通畅率。使用血管多普勒超声、电磁流量计和病理检查(术后 6 周)评估吻合动脉的通畅情况:结果:采用聚乳酸-共聚乙醇酸原料和三维打印技术,成功设计并制造了新型动脉耦合器 QAC。通过有限元分析和相关力学分析方法对其合理性进行了初步测试。在体外测试中,离体动脉在 QAC 的辅助下成功吻合,显示出良好的抗牵引性。在动物实验中,QAC 辅助动脉吻合术在吻合时间(7.80 ± 1.41 vs. 16.38 ± 1.04 分钟)、夹持时间(8.80 ± 1.41 vs. 14.14 ± 1.57 分钟)和总手术时间(46.64 ± 2.38 vs. 51.96 ± 3.65 分钟)方面均优于手缝吻合术。电磁流量计、血管多普勒超声和病理检查结果表明,QAC辅助吻合动脉的术后血流量(16.86 ± 3.93 vs. 10.36 ± 0.92 mL/min)和术后6周的血管通畅度均优于手缝动脉:结论:QAC 是一种设计精良、易于操作的装置,专门用于端对端动脉吻合术。结论:QAC 是一种设计精良、易于操作的装置,专门用于端对端动脉吻合术,应用该装置可缩短热缺血时间,改善吻合动脉的通畅性,从而改善预后。
{"title":"A novel arterial coupler with non-return snap-fit connection approach optimized arterial end-to-end anastomotic technique: An experimental study.","authors":"Hong-Bo Guo, Mo-Fei Wang, Ren-Qi Yin, Kang-Kang Zhi","doi":"10.1016/j.cjtee.2024.09.006","DOIUrl":"10.1016/j.cjtee.2024.09.006","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;Hand-sewn anastomosis as the gold standard of vascular anastomosis cannot fully meet the requirements of vascular anastomosis in speed and quality. Various vascular couplers have been developed to ameliorate this situation. Most of them are mainly used for venous anastomosis rather than arterial anastomosis. Although it is generally acknowledged that in almost all operations involving vascular reconstruction, it is the arteries that need to be anastomosed faster and more accurately and not the veins. A dedicated device is needed for creating arterial anastomosis in an easy, timesaving, less damaging but reliable procedure. Therefore, we plan to develop a novel arterial coupler device and test pre-clinical safety and effectiveness.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In this cohort study, the rationality of this novel arterial coupler was preliminarily tested by finite element analysis before it was manufactured. Several factors restrict the use of vascular couplers in arterial anastomosis, such as arterial eversion, fixation, etc. The manufactured arterial couplers underwent in vitro and in vivo experiments. In vitro, isolated arteries of beagles were anastomosed with the assistance of an arterial coupler, and the anastomosed arteries were evaluated through anti-traction tests. In animal experiments, the bilateral femoral arteries of 5 beagles served as a control group. After dissection, the femoral artery on one side was randomly selected to be anastomosed with a quick arterial coupler (QAC) (QAC group), and the femoral artery on the other side was anastomosed by the same person using an end-to-end suture technique with a 6-0 Prolene suture (suture group). The bilateral femoral arteries of 5 beagles were used for coupler-assisted anastomosis and hand-sewn anastomosis in vivo, respectively. Success rate, blood loss, anastomotic time, clamp time, total operation time, and patency rate were recorded. The patency of anastomosed arteries was assessed using vascular Doppler ultrasound, electromagnetic flowmeter, and pathological examination (6 weeks after surgery).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;As a novel arterial coupler, QAC was successfully designed and manufactured by using poly lactic-co-glycolic acid raw materials and 3-dimensions printing technology. Its rationality was preliminarily tested through finite element analysis and related mechanical analysis methods. The isolated arteries were successfully anastomosed with the assistance of QAC in vitro testing, which showed good anti-traction properties. In animal studies, QAC-assisted arterial anastomosis has superior profiles compared to hand-sewn anastomosis in anastomotic time (7.80 ± 1.41 vs. 16.38 ± 1.04 min), clamp time (8.80 ± 1.41 vs. 14.14 ± 1.57 min), and total operation time (46.64 ± 2.38 vs. 51.96 ± 3.65 min). The results of electromagnetic flowmeter, vascular Doppler ultrasound, and pathological examination showed that QAC-assisted anastomotic arteries were ","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":"13-21"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142480426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stent-graft implantation for late postpancreatectomy hemorrhage after pancreatoduodenectomy. 胰十二指肠切除术后晚期胰腺切除术后出血的支架移植术。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-10-29 DOI: 10.1016/j.cjtee.2024.08.009
Xiaoye Li, Shibo Xia, Liangxi Yuan, Lei Zhang, Chao Song, Xiaolong Wei, Qingsheng Lu

Purpose: Postpancreatectomy hemorrhage (PPH) is a life-threatening complication after pancreatoduodenectomy. Stent-graft implantation is an emerging treatment option for PPH. This study reports the outcome of PPH treated with stent-graft implantation.

Methods: This was a single-center, retrospective study. Between April 2020 and December 2023, 1723 pancreatectomy cases were collected while we screened 12 cases of PPH after pancreatoduodenectomy treated with stent-graft implantation. Patients' medical and radiologic images were retrospectively reviewed. Technical and clinical success, complications, and stent-graft patency were evaluated. Continuous data are reported as means ± standard deviation when normally distributed or as median (Q1, Q3) when the data is non-normal distributed. Categorical data are reported as n (%). A p < 0.05 was considered statistically significant. Kaplan-Meier estimates were used for stent patency and patients' survival.

Results: Pancreatic fistula was identified in 6 cases (50.0%), and pseudoaneurysm was identified in 3 cases (25.0%), including pancreatic fistula together with pseudoaneurysm in 1 case (8.3%). All pseudoaneurysm or contrast extravasation sites were successfully excluded with patent distal perfusion, thus technical success was achieved in all cases. The overall survival rate at 6 months and 1 year was 91.7% and 78.6%, respectively. One patient had herniation of the small intestine into the thoracic cavity, which caused a broad thoracic and abdominal infection and died during hospitalization. Rebleeding occurred at the gastroduodenal artery stump in 1 case after stent-graft implantation for the splenic artery and was successfully treated with another stent-graft implantation. Two cases of asymptomatic stent-graft occlusion were observed at 24.6 and 26.3 after the operation, respectively.

Conclusions: With suitable anatomy, covered stent-graft implantation is an effective and safe treatment option for PPH with various bleeding sites and causes.

目的:胰腺切除术后出血(PPH)是胰十二指肠切除术后一种危及生命的并发症。支架移植物植入术是治疗 PPH 的新兴疗法。本研究报告了采用支架移植物植入术治疗 PPH 的结果:这是一项单中心回顾性研究。在2020年4月至2023年12月期间,我们收集了1723例胰腺切除术病例,并筛选出12例胰十二指肠切除术后使用支架移植物植入治疗PPH的病例。我们对患者的医疗和放射影像进行了回顾性审查。对技术和临床成功率、并发症以及支架移植物的通畅性进行了评估。连续数据在呈正态分布时以均数 ± SD 表示,在呈非正态分布时以中位数(Q1、Q3)表示。分类数据以 n(%)表示。P 值 结果:发现胰瘘 6 例(50.0%),假性动脉瘤 3 例(25.0%),其中胰瘘合并假性动脉瘤 1 例(8.3%)。所有假性动脉瘤或造影剂外渗部位均成功排除,远端灌注通畅,因此所有病例均取得了技术成功。6 个月和 1 年的总存活率分别为 91.7% 和 78.6%。一名患者的小肠疝入胸腔,造成胸腔和腹腔广泛感染,在住院期间死亡。1例患者在为脾动脉植入支架后,胃十二指肠动脉残端发生再出血,经再次植入支架后成功治愈。术后 24.6 和 26.3 天分别观察到两例无症状支架移植物闭塞:在解剖结构合适的情况下,覆盖支架移植物植入术是治疗不同出血部位和原因的 PPH 的有效而安全的选择。
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引用次数: 0
4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain. 伊塔康酸 4-辛酯可抑制创伤后骨关节炎小鼠模型中的滑膜炎并减轻疼痛。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-11-09 DOI: 10.1016/j.cjtee.2024.10.001
Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang
<p><strong>Purpose: </strong>To investigate the pathological changes of the synovium in mice with post-traumatic osteoarthritis (PTOA) treated with 4-octyl itaconate (4-OI) and evaluate the therapeutic effects of 4-OI.</p><p><strong>Methods: </strong>In the phenotypic validation experiment, the mice were randomly divided into 3 groups: wild-type (WT) group, sham group, and destabilization of the medial meniscus (DMM) group. Through MRI, micro-CT, and histological analysis, it was determined that the DMM surgery induced a mouse PTOA model with significant signs of synovitis. At 12 weeks post-DMM surgery, synovial tissues from the DMM group and WT group mice were collected for ribonucleic acid sequencing analysis. In the 4-OI treatment experiment, mice were randomly divided into the sham group, DMM group, DMM + 4-OI (50 mg/kg) group, and DMM + 4-OI (100 mg/kg) group. Von Frey tests and open field tests were conducted at intervals during the 12 weeks following the DMM surgery. After 12 weeks of surgery, the efficacy of 4-OI treatment on PTOA in mice was evaluated using MRI, micro-CT, histological analysis, and quantitative real-time polymerase chain reaction. Finally, we utilized network pharmacology analysis to predict the mechanism of 4-OI in treating PTOA synovitis and conducted preliminary validation. Statistical analysis was performed using one-way ANOVA and the Kruskal-Wallis test. Difference was considered statistically significant at p < 0.05.</p><p><strong>Results: </strong>The DMM surgery effectively induced a PTOA mouse model, which displayed significant symptoms of synovitis. These symptoms included a notable increase in both the number of calcified tissues and osteophytes (p < 0.001), an enlargement of the calcified meniscus and synovial tissue volume (p < 0.001), and thickening of the synovial lining layer attributable to M1 macrophage accumulation (p = 0.035). Additionally, we observed elevated histological scores for synovitis (p < 0.001). Treatment with 4-OI inhibited the thickening of M1 macrophages in the synovial lining layer of PTOA mice (p < 0.001) and reduced fibrosis in the synovial stroma (p = 0.004). Furthermore, it reduced the histological scores of knee synovitis in PTOA mice (p = 0.006) and improved the inflammatory microenvironment associated with synovitis. Consequently, this treatment alleviated pain in PTOA mice (p < 0.001) and reduced spontaneous activity (p = 0.003). Bioinformatics and network pharmacology analyses indicated that 4-OI may exert its therapeutic effects by inhibiting the differentiation of synovial Th17 cells. Specifically, compared to the lipopolysaccharide stimulation group, 4-OI reduced the levels of positive regulatory factors of Th17 cell differentiation (IL-1: p < 0.001, IL-6: p < 0.001), key effector molecules (IL-17A: p < 0.001, IL-17F: p = 0.004), and downstream effector molecules in the IL-17 signaling pathway (CCL2: p < 0.001, MMP13: p < 0.001).</p><p><strong>Conclusion: </strong>4-OI is e
目的:研究使用伊他康酸 4-辛酯(4-OI)治疗创伤后骨关节炎(PTOA)小鼠滑膜的病理变化,并评估 4-OI 的治疗效果:在表型验证实验中,小鼠被随机分为三组:野生型(WT)组、假组和内侧半月板失稳(DMM)组。通过核磁共振成像、显微 CT 和组织学分析,确定 DMM 手术诱导的小鼠 PTOA 模型有明显的滑膜炎症状。在 DMM 手术后 12 周,收集 DMM 组和 WT 组小鼠的滑膜组织进行核糖核酸测序分析。在 4-OI 治疗实验中,小鼠被随机分为假组、DMM 组、DMM + 4-OI (50 mg/kg) 组和 DMM + 4-OI (100 mg/kg) 组。在 DMM 手术后的 12 周内,每隔一段时间进行一次 Von Frey 试验和野外开放试验。手术 12 周后,我们使用 MRI、Micro-CT、组织学分析和定量实时 PCR 评估了 4-OI 治疗对小鼠 PTOA 的疗效。最后,我们利用网络药理学分析预测了 4-OI 治疗 PTOA 滑膜炎的机制,并进行了初步验证。统计分析采用单因素方差分析和 Kruskal-Wallis 检验:结果:DMM手术有效地诱导了PTOA小鼠模型,该模型出现了明显的滑膜炎症状。这些症状包括钙化组织和骨质增生的数量明显增加(p 结论:4-OI 能有效抑制滑膜炎的发生:4-OI 能有效抑制 PTOA 的滑膜炎,从而减轻相关的疼痛症状。
{"title":"4-Octyl itaconate inhibits synovitis in the mouse model of post-traumatic osteoarthritis and alleviates pain.","authors":"Yu-Zhen Tang, Wan Chen, Bao-Yun Xu, Gang He, Xiu-Cheng Fan, Kang-Lai Tang","doi":"10.1016/j.cjtee.2024.10.001","DOIUrl":"10.1016/j.cjtee.2024.10.001","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To investigate the pathological changes of the synovium in mice with post-traumatic osteoarthritis (PTOA) treated with 4-octyl itaconate (4-OI) and evaluate the therapeutic effects of 4-OI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;In the phenotypic validation experiment, the mice were randomly divided into 3 groups: wild-type (WT) group, sham group, and destabilization of the medial meniscus (DMM) group. Through MRI, micro-CT, and histological analysis, it was determined that the DMM surgery induced a mouse PTOA model with significant signs of synovitis. At 12 weeks post-DMM surgery, synovial tissues from the DMM group and WT group mice were collected for ribonucleic acid sequencing analysis. In the 4-OI treatment experiment, mice were randomly divided into the sham group, DMM group, DMM + 4-OI (50 mg/kg) group, and DMM + 4-OI (100 mg/kg) group. Von Frey tests and open field tests were conducted at intervals during the 12 weeks following the DMM surgery. After 12 weeks of surgery, the efficacy of 4-OI treatment on PTOA in mice was evaluated using MRI, micro-CT, histological analysis, and quantitative real-time polymerase chain reaction. Finally, we utilized network pharmacology analysis to predict the mechanism of 4-OI in treating PTOA synovitis and conducted preliminary validation. Statistical analysis was performed using one-way ANOVA and the Kruskal-Wallis test. Difference was considered statistically significant at p &lt; 0.05.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The DMM surgery effectively induced a PTOA mouse model, which displayed significant symptoms of synovitis. These symptoms included a notable increase in both the number of calcified tissues and osteophytes (p &lt; 0.001), an enlargement of the calcified meniscus and synovial tissue volume (p &lt; 0.001), and thickening of the synovial lining layer attributable to M1 macrophage accumulation (p = 0.035). Additionally, we observed elevated histological scores for synovitis (p &lt; 0.001). Treatment with 4-OI inhibited the thickening of M1 macrophages in the synovial lining layer of PTOA mice (p &lt; 0.001) and reduced fibrosis in the synovial stroma (p = 0.004). Furthermore, it reduced the histological scores of knee synovitis in PTOA mice (p = 0.006) and improved the inflammatory microenvironment associated with synovitis. Consequently, this treatment alleviated pain in PTOA mice (p &lt; 0.001) and reduced spontaneous activity (p = 0.003). Bioinformatics and network pharmacology analyses indicated that 4-OI may exert its therapeutic effects by inhibiting the differentiation of synovial Th17 cells. Specifically, compared to the lipopolysaccharide stimulation group, 4-OI reduced the levels of positive regulatory factors of Th17 cell differentiation (IL-1: p &lt; 0.001, IL-6: p &lt; 0.001), key effector molecules (IL-17A: p &lt; 0.001, IL-17F: p = 0.004), and downstream effector molecules in the IL-17 signaling pathway (CCL2: p &lt; 0.001, MMP13: p &lt; 0.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;4-OI is e","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":"50-61"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142693750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in the management of chronic ankle instability. 慢性踝关节不稳定治疗的最新进展。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-11-07 DOI: 10.1016/j.cjtee.2024.07.011
Yimeng Yang, Yang Wu, Wenhui Zhu

Ankle sprains are the most common lesion of the ankle joint which might result in chronic ankle instability (CAI). Significant strides have been taken to enhance our comprehension of the underlying mechanisms of CAI, as the exploration of novel surgical techniques and the identification of previously unrecognized anatomical components. The present review aims to provide an extensive overview of CAI, encompassing its pathophysiology, epidemiology, clinical assessment, treatment, and rehabilitation. Treatment of CAI requires a multifaceted algorithm, involving historical analysis, clinical evaluations, and diagnostic imaging. Surgical interventions for CAI primarily involve the anatomical and/or non-anatomical reconstruction and/or repair of the anterior talofibular ligament. Anatomical repair has exhibited superior functional outcomes and a reduced risk of secondary osteoarthritis compared to non-anatomical repair. Non-anatomical approaches fall short of replicating the normal biomechanics of the anterior talofibular ligament, potentially leading to postoperative stiffness. This review seeks to academically review and up-to-date literature on this issue, tailored for clinical practice, with the intent of aiding surgeons in staying abreast of this critical subject matter.

踝关节扭伤是踝关节最常见的损伤,可能导致慢性踝关节不稳定(CAI)。随着对新型手术技术的探索和对以前未曾认识到的解剖学成分的识别,我们对 CAI 潜在机制的理解有了长足的进步。本综述旨在广泛概述 CAI,包括其病理生理学、流行病学、临床评估、治疗和康复。CAI 的治疗需要多方面的算法,包括历史分析、临床评估和影像诊断。CAI 的手术干预主要涉及解剖和/或非解剖重建和/或修复距骨胫骨前韧带。与非解剖性修复相比,解剖性修复的功能效果更好,继发性骨关节炎的风险也更低。非解剖方法无法复制距骨胫骨前韧带的正常生物力学,可能导致术后僵硬。本综述旨在对这一问题的最新文献进行学术回顾,为临床实践量身定制,目的是帮助外科医生了解这一关键主题。
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引用次数: 0
Two cases of complex traumatic aortic dissection combined with multiple organ injuries. 两例复杂的外伤性主动脉夹层合并多器官损伤。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-08-05 DOI: 10.1016/j.cjtee.2024.08.001
Qingpeng Song, Lili Bao, Xuejun Wu, Bingqi Liu, Maohua Wang

Traumatic aortic injury (TAI) is an acute, critical, and severe disease, and then combined with multiple organ damage, it is even more dangerous. TAI progresses very rapidly, with a pre-hospital mortality rate of 57%-80%, and even when arriving at the hospital, more than one-third of the patients die within 4 h, and it is the 2nd leading cause of death in individuals aged 4-34 years. In addition, the incidence of TAI combined with injury was 81.4%. Therefore, early diagnosis, expeditious surgery, and timely and effective multidisciplinary cooperation are essential for successful rescue. The authors report 2 patients with acute traumatic aortic dissection combined with multiple organ injuries and treated with emergency endovascular surgery to discuss their clinical characteristics and treatment experience, and to provide experience in the diagnosis and treatment of such patients.

创伤性主动脉损伤(TAI)是一种急性、危重的严重疾病,再加上多器官损伤,就更加危险了。创伤性主动脉损伤进展非常迅速,院前死亡率高达 57% - 80%,即使到达医院,也有超过三分之一的患者在 4 小时内死亡,是 4 - 34 岁人群的第二大死因。此外,TAI合并损伤的发生率为81.4%。因此,早期诊断、快速手术、及时有效的多学科合作是成功抢救的关键。作者报告了2例急性创伤性主动脉夹层合并多脏器损伤并接受急诊血管内手术治疗的患者,探讨其临床特点和治疗经验,为此类患者的诊断和治疗提供经验。
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引用次数: 0
Evaluating the effectiveness of immediate vs. elective thoracic endovascular aortic repair for blunt thoracic aortic injury. 评估钝性胸主动脉损伤时立即进行胸腔内血管主动脉修补术与择期进行胸腔内血管主动脉修补术的效果。
IF 1.8 4区 医学 Q2 ORTHOPEDICS Pub Date : 2025-01-01 Epub Date: 2024-08-05 DOI: 10.1016/j.cjtee.2024.08.002
Zhaohui Hua, Baoning Zhou, Wenhao Xue, Zhibin Zhou, Jintao Shan, Lei Xia, Yunpeng Luo, Yiming Chai, Zhen Li
<p><strong>Purpose: </strong>To evaluate the relationship between the timing of thoracic endovascular aortic repair (TEVAR) for blunt thoracic aortic injury (BTAI) and prognosis.</p><p><strong>Methods: </strong>This is a single-center retrospective cohort study. Patients who received TEVAR for BTAI at our institution from October 2016 to September 2023 were divided into 2 categories depending on the injury severity score (ISS) (≤ 25 vs. > 25) and when the TEVAR was performed for BTAI (within 24 h vs. after 24 h), respectively. The analysis included all patients who received TEVAR treatment after being diagnosed with BTAI through whole-body CT angiography. Patients treated with open repair and non-operative management were excluded. After propensity-score matching for various factors, outcomes during hospitalization and follow-up were compared. These factors included demographics, comorbidities, concomitant injuries, cause and location of aortic injury, Glasgow coma scale score, society for vascular surgery grading, hemoglobin concentration, creatinine concentration, shock, systolic blood pressure, and heart rate at admission. The comparison was conducted using SPSS 26 software. Continuous variables were presented as either the mean ± standard deviation or median (Q<sub>1</sub>, Q<sub>3</sub>), and were compared using either the t-test or the Mann-Whitney U test. Categorical variables were expressed as n (%), and comparisons were made between the 2 groups using the χ<sup>2</sup> test or Fisher's exact test. Statistical significance was defined as a 2-sided p < 0.05.</p><p><strong>Results: </strong>In total, 110 patients were involved in the study, with 65 (59.1%) patients having ISS scores > 25 and 32 (29.1%) receiving immediate TEVAR. The perioperative overall mortality rate in the group with ISS > 25 was significantly higher than that in the group with ISS ≤ 25 (11 (16.9%) vs. 2 (4.4%), p < 0.001). Upon admission, the elective group exhibited a notably higher Glasgow coma scale score (median (Q<sub>1</sub>, Q<sub>3</sub>)) compared to the immediate group (15 (12, 15) vs. 13.5 (9, 15), p = 0.039), while the creatinine concentration (median (Q<sub>1</sub>, Q<sub>3</sub>)) at admission was significantly higher in the immediate group (90.5 (63.8, 144.0) vs. 71.5 (58.3, 80.8), p = 0.012). The final sample included 52 matched patients. Complications occurred significantly less frequently in the elective group compared to the immediate group (16 (50.0%) vs. 3 (10.0%), p < 0.001). Single-factor analysis of variance showed that complications in hospitalized patients were significantly associated with immediate TEVAR as the sole independent risk factor (odds ratio: 9.000, 95% confidence interval: 2.266-35.752, p = 0.002).</p><p><strong>Conclusion: </strong>In this propensity-score matched analysis of patients undergoing TEVAR for BTAI, elective TEVAR was significantly associated with a lower risk of complication rates. In this study using propensity-score
目的:评估钝性胸主动脉损伤(BTAI)胸腔内血管主动脉修复术(TEVAR)的时机与预后之间的关系:这是一项单中心回顾性队列研究。根据损伤严重程度评分(ISS)(≤ 25 vs. >25)和为 BTAI 实施 TEVAR 的时间(24 h 内 vs. 24 h 后),将 2016 年 10 月至 2023 年 9 月期间在我院接受 TEVAR 的 BTAI 患者分为两类。分析包括所有通过全身 CT 血管造影确诊为 BTAI 后接受 TEVAR 治疗的患者。不包括接受开放式修复和非手术治疗的患者。在对各种因素进行倾向分数匹配后,对住院期间和随访期间的结果进行了比较。这些因素包括入院时的人口统计学特征、合并症、并发症、主动脉损伤的原因和部位、格拉斯哥昏迷量表评分、血管外科学会分级、血红蛋白浓度、肌酐浓度、休克、收缩压和心率。比较使用 SPSS 26 软件进行。连续变量以均数±标准差或中位数(Q1、Q3)表示,采用 t 检验或 Mann-Whitney U 检验进行比较。分类变量以 n(%)表示,两组间的比较采用 χ2 检验或费雪精确检验。统计显著性定义为双侧 P < 0.05:共有110名患者参与了研究,其中65名(59.1%)患者的ISS评分大于25分,32名(29.1%)患者立即接受了TEVAR。与即刻手术组相比,ISS>25组的围手术期总死亡率明显高于ISS≤25组(11 (16.9%) vs. 2 (4.4%),P 1, Q3)(15 (12, 15) vs. 13.5 (9, 15))。而入院时肌酐浓度(中位数(Q1,Q3))则明显高于即时组(90.5(63.8,144.0)vs 71.5(58.3,80.8),p = 0.012)。最终样本包括 52 名匹配的患者。与即刻手术组相比,择期手术组发生并发症的频率明显较低(16 例(50.0%)对 3 例(10.0%),P=0.012):在这项对因 BTAI 而接受 TEVAR 的患者进行的倾向得分匹配分析中,选择性 TEVAR 与较低的并发症发生率风险明显相关。在这项使用倾向分数匹配的研究中,因 BTAI 而接受择期 TEVAR 的患者的并发症发生率低于立即接受 TEVAR 的患者。
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引用次数: 0
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Chinese Journal of Traumatology
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