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Comment on "Dental trauma related to orotracheal intubation". 对“口气管插管所致牙外伤”的评论。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-01-29 DOI: 10.1016/j.cjtee.2025.03.005
Anju Gupta, Amiya Kumar Barik, Rakesh Vadakkethil Radhakrishnan, Chitta Ranjan Mohanty
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引用次数: 0
First exploration of three-dimensional-printed guide plate in balloon tibioplasty: A case report. 三维打印引导板在球囊胫骨成形术中的首次探索:1例报告。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-01-27 DOI: 10.1016/j.cjtee.2025.03.006
Wen-Long Liu, Yu Nie, Lei Dong, Zheng-Zheng Xiao, Da-Shuai Liu

To overcome the drawbacks of traditional balloon tibioplasty (BT), this study designed a complete scheme for applying 3-dimensional (3D)-printed guide plate to BT, and preliminarily verified the feasibility. The authors report a patient with tibial plateau fracture. 3D models were constructed using CT data of patient. Guided K-wires and reduction fragments were generated using the Mimics/Geomagic software. A 3D model of the quasi-platform part was subsequently generated using the outer platform surface profile. Extension arms and Kirschner pinholes were generated by sketching, wrapping, shearing, and performing Boolean and other operations. The guide plate was created using 3D printing and surgically verified. The verification results showed that the quasi-platform part was placed smoothly, fitted the physiological curvature of the articular surface, and maintained stable reduction, demonstrating the feasibility of the guide plate. Compared with traditional BT, 3D-printed guide plate-assisted BT has the theoretical advantages of accurate reduction, prevention of bone cement leakage, short operation time, and low surgical difficulty, thus providing a new method for the treatment of Schatzker type II/III tibial plateau fractures.

为克服传统球囊式胫成形术(BT)的不足,本研究设计了一套完整的3D打印引导板应用于BT的方案,并初步验证了其可行性。作者报告了一例胫骨平台骨折患者。利用患者CT数据建立三维模型。使用Mimics/Geomagic软件生成引导k线和复位碎片。随后,利用外平台表面轮廓生成准平台零件的三维模型。通过绘制草图、包裹、剪切和执行布尔等操作生成延伸臂和克氏针孔。导板是使用3D打印创建的,并进行了手术验证。验证结果表明,准平台部分放置平稳,拟合关节面生理曲率,复位稳定,证明了导板的可行性。与传统BT相比,3d打印导板辅助BT具有复位准确、防止骨水泥渗漏、手术时间短、手术难度低等理论上的优势,为Schatzker II/III型胫骨平台骨折的治疗提供了一种新的方法。
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引用次数: 0
Optimization of chest deflection definition in human body models: Implication for pedestrian injury assessment. 人体模型中胸部偏转定义的优化:对行人损伤评估的意义。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-01-23 DOI: 10.1016/j.cjtee.2025.10.005
Guojie Wang, Yongcheng Long, Bing Zhang, Yu Xiao, James Cheng, Yi Chang, Yu Liu

Purpose: Pedestrian chest injuries remain a significant global concern, ranking as the second leading cause of death in traffic accidents. Although human body model (HBM) provides a strain-based methodology for predicting pedestrian chest injuries, conventional deflection-based injury metrics remain valuable due to their hard validation of HBM biofidelity at the tissue response level. Consequently, achieving accurate chest injury assessment through HBM technology represents a critical biomechanical research challenge. This study aims to identify the optimal method for defining thorax deflection in HBM to improve injury assessment in vehicle-pedestrian collisions.

Methods: A simulation matrix was designed, incorporating 5 different vehicle front-end types, 3 impact angles, 4 collision speeds, and 2 pedestrian postures, resulting in a total of 120 pedestrian-vehicle collision simulations. The simulations utilized the Total Human Model for Safety version 4.02 pedestrian model and predefined chest bands spanning from the upper to the lower chest. A total of 4 distinct methods for defining chest deflection were tested across the simulations. Principal component analysis was applied for dimensionality reduction to further refine the analysis. Two biomechanically distinct injury risk functions were employed to assess chest injury: the strain-based method, incorporating principal strain distributions across 12 ribs, and the deflection-based method, based on our pre-defined 6 chest band measurements.

Results: Our experimental findings reveal that injury risk decreases initially as the bonnet leading edge height increases, reaching a minimum around 950 mm with abbreviated injury scale 3+ and the number of fractured ribs (NFR) 3+ risk below 0.2, and then increasing thereafter. The study also demonstrated minimal chest injury risk acrossNFR2+/NFR3+ and NFR7+ conditions, with NFR risk below 0.2, despite localized high rib strain observed in certain individual ribs up to 8.28 × 10-3. Meanwhile, A newly developed index termed PC_deflection, which is derived from the sum of the products of the weighting factors corresponding to 2 optimal thorax deflection measurement methods with NFR3+ correlation coefficients of 0.743 and 0.753, was identified as an effective predictor of injury risk in HBM simulations.

Conclusion: This study successfully determined the optimal method for measuring thorax deflection for HBM chest injury prediction, which could serve as a complementary metric for pedestrian chest injury assessment.

目的:行人胸部损伤仍然是全球关注的一个重要问题,是交通事故死亡的第二大原因。尽管人体模型(HBM)提供了一种基于应变的方法来预测行人胸部损伤,但传统的基于偏转的损伤指标仍然有价值,因为它们在组织反应水平上对HBM的生物保真度进行了严格的验证。因此,通过HBM技术实现准确的胸部损伤评估是一项关键的生物力学研究挑战。本研究旨在确定确定HBM中胸部偏转的最佳方法,以提高车辆-行人碰撞中的伤害评估。方法:设计了包含5种不同车辆前端类型、3种碰撞角度、4种碰撞速度和2种行人姿态的仿真矩阵,共进行了120次人车碰撞仿真。模拟使用了Total Human Model for Safety version 4.02行人模型和从上到下胸部的预定义胸带。在模拟中,总共测试了4种不同的方法来定义胸部偏转。采用主成分分析进行降维,进一步细化分析。采用两种生物力学上不同的损伤风险函数来评估胸部损伤:基于应变的方法,包括12根肋骨的主要应变分布,以及基于我们预先定义的6个胸带测量的基于挠度的方法。结果:实验结果表明,随着发动机罩前缘高度的增加,损伤风险开始降低,在950 mm左右达到最小值,损伤等级为3+,骨折肋骨数(NFR) 3+风险小于0.2,之后损伤风险逐渐增加。该研究还表明,snfr2 +/NFR3+和NFR7+条件下的胸部损伤风险最小,NFR风险低于0.2,尽管在某些个体肋骨中观察到局部高肋骨应变高达8.28 × 10-3。同时,通过2种最佳胸挠度测量方法对应的加权因子(NFR3+相关系数分别为0.743和0.753)的乘积和,建立了一个新的指标pc_挠度,该指标可有效预测HBM模拟中的损伤风险。结论:本研究成功确定了用于HBM胸部损伤预测的最佳测量方法,可作为行人胸部损伤评估的补充指标。
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引用次数: 0
Global epidemiology of hip fractures in adults aged 70 years and older from 1990 to 2021: a cross-sectional analysis from Global Burden of Disease Study 2021. 1990年至2021年70岁及以上成人髋部骨折的全球流行病学:来自2021年全球疾病负担研究的横断面分析
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-01-23 DOI: 10.1016/j.cjtee.2025.12.001
Yanqiu Wang, Lu Tan, Jiaxin Dong, Jun Zhang, Jie Zhu, Yuan Zhang

Purpose: Driven by population aging, osteoporosis, and the frequent coexistence of multiple chronic conditions, hip fractures mainly occur in adults aged ≥70 years. Nevertheless, the specific burden attributable to this population remains insufficiently understood. This study sought to address key gaps in the literature by analyzing the Global Burden of Disease 2021 dataset to investigate hip fracture patterns across age, sex, and sociodemographic index (SDI).

Methods: We extracted hip fracture incidence, prevalence, years lived with disability (YLD), and age-standardized rates from the Global Burden of Disease 2021 database and stratified the data by age, sex, SDI, and geographic regions. Temporal trends were assessed by Joinpoint Regression Analysis and average annual percentage change, while uncertainty intervals were calculated to reflect modeling variability.

Results: From 1990 to 2021, the global burden of hip fractures in adults aged ≥70 years increased significantly, with age-standardized prevalence rates climbing from 3521.6 to 4366.8 per 100,000 and age-standardized incidence rates increasing from 1866.9 to 2218.5 per 100,000, whereas the age-standardized YLD rate demonstrated minimal growth (384.4-386.5 per 100,000). Notably, a persistent gender gap was observed, with females bearing a higher absolute burden, while males exhibited significantly faster growth rates in prevalence, incidence, and YLD. Moreover, the burden increased dramatically with advancing age. Geographically, high-SDI regions retained the highest absolute caseload; middle-SDI regions exhibited the fastest-growing prevalence and incidence rates, whereas low-SDI regions recorded the highest YLD rate.

Conclusions: Global hip fracture burden in adults aged ≥70 years arises from aging populations, biological vulnerabilities, and healthcare inequities. High-income nations face the largest caseloads due to demographic shifts, while low-resource settings grapple with rising disability rates from delayed diagnosis and limited care. Effective mitigation requires age-specific osteoporosis screening, fall prevention programs, and multidisciplinary care, demanding collaborative efforts for equitable resource allocation and regional-tailored strategies in aging populations worldwide.

目的:受人口老龄化、骨质疏松以及多种慢性疾病多发的影响,髋部骨折主要发生在≥70岁的成年人中。然而,可归因于这一人口的具体负担仍然没有得到充分了解。本研究通过分析2021年全球疾病负担数据集,调查不同年龄、性别和社会人口指数(SDI)的髋部骨折模式,试图解决文献中的关键空白。方法:我们从全球疾病负担2021数据库中提取髋部骨折发生率、患病率、残疾生活年数(YLD)和年龄标准化率,并按年龄、性别、SDI和地理区域对数据进行分层。通过连接点回归分析和平均年百分比变化评估时间趋势,同时计算不确定区间以反映建模变异性。结果:从1990年到2021年,全球≥70岁成人髋部骨折负担显著增加,年龄标准化患病率从3521.6 / 10万上升到4366.8 / 10万,年龄标准化发病率从1866.9 / 10万上升到2218.5 / 10万,而年龄标准化YLD的增长最小(384.4 / 10万-386.5 / 10万)。值得注意的是,观察到持续的性别差异,女性承担更高的绝对负担,而男性在患病率、发病率和YLD方面表现出明显更快的增长速度。此外,随着年龄的增长,这种负担急剧增加。从地理上看,高sdi地区保持了最高的绝对病例量;中等sdi地区的患病率和发病率增长最快,而低sdi地区的患病率最高。结论:全球≥70岁成人髋部骨折负担源于人口老龄化、生物脆弱性和医疗不公平。由于人口结构的变化,高收入国家面临的病例量最大,而低资源国家则面临因诊断延误和护理有限而导致的残疾率上升的问题。有效的缓解需要针对特定年龄的骨质疏松症筛查、跌倒预防计划和多学科护理,这需要在全球老龄化人口中进行公平的资源分配和区域定制战略的合作努力。
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引用次数: 0
Superselective angioembolization of segmental renal artery in grade 4 renal trauma: A case report. 4级肾外伤肾段性动脉超选择性血管栓塞1例。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-01-13 DOI: 10.1016/j.cjtee.2025.05.004
Deepak Kumar, Majid Anwer, Anurag Kumar, Anil Kumar

Genitourinary tract injury is involved in around 10% of blunt abdominal trauma, with the kidney accounting for most cases. Surgical treatment in the form of exploration has been traditionally used to control bleeding. Newer advances in interventional radiology, with improvement in precise imaging and the localization of bleeding vessels, have led to a high success rate of angioembolization. We describe here a case of grade 4 right renal injury that underwent successful superselective angioembolization of the renal artery. A 26-year-old male presented to the emergency department of the trauma center, All India Institute of Medical Sciences, Patna with an alleged history of road traffic injury. A contrast-enhanced CT abdomen was done, which showed grade 4 right renal injury with active contrast leak from the branch of the right renal artery. On post-injury day 1, he had a drop in hematocrit/hemoglobin. He also had more progressive hematuria. He was shifted to the digital subtraction angiography room, where imaging showed contrast extravasation from a branch of the right middle segmental renal artery. There was no contrast extravasation seen after coil embolization. He was discharged after 1 week of hospital stay. He came for follow-up after 4 weeks, where a renal function test was normal and repeat ultrasonography of the abdomen showed a focal defect with scarring of the right renal mid-pole, along with mild right pyelectasis and maintained vascularity at all renal poles. The major cause of bleeding after renal trauma is due to rupture of the renal artery and its branches. Such a patient undergoes a routine CT with contrast to determine the source and grade of renal injury. Such cases are now best managed using superselective angioembolization, depending on the availability of interventional radiology.

约10%的钝性腹部外伤涉及泌尿生殖系统损伤,其中肾脏损伤占大多数。传统上采用探查形式的手术治疗来控制出血。介入放射学的最新进展,随着精确成像和出血血管定位的提高,导致了血管栓塞的高成功率。我们在这里描述一个4级右肾损伤的病例,成功地进行了肾动脉超选择性血管栓塞。一名26岁男性,据称有道路交通伤害史,到巴特那全印度医学科学研究所创伤中心急诊科就诊。腹部增强CT示右肾4级损伤,伴右肾动脉支造影剂活动性渗漏。在受伤后第1天,他的红细胞压积/血红蛋白下降。他还出现了更严重的血尿。他被转移到数字减影血管造影室,在那里成像显示造影剂从右肾中段动脉分支外渗。线圈栓塞后未见造影剂外渗。住院1周后出院。患者于4周后接受随访,肾功能检查正常,腹部重复超声检查显示右肾中极局灶性缺损伴瘢痕形成,伴轻度右侧肾盂扩张,各肾极维持血管通畅。肾外伤后出血的主要原因是肾动脉及其分支的破裂。这样的患者接受常规CT造影以确定肾损伤的来源和级别。这类病例目前最好的治疗方法是使用超选择性血管栓塞,这取决于介入放射学的可用性。
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引用次数: 0
A prospective study exploring parathyroid hormone as a biomarker in haemorrhagic shock resuscitation. 一项探讨甲状旁腺激素作为失血性休克复苏生物标志物的前瞻性研究。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-01-05 DOI: 10.1016/j.cjtee.2025.09.003
Dinesh Kumar Bagaria, Shailly Gupta, S Arul Selvi, Shivam Pandey, Narendra Choudhary, Junaid Alam, Pratyusha Priyadarshini, Abhinav Kumar, Biplab Mishra, Sushma Sagar, Subodh Kumar, Amit Gupta

Purpose: Lactate and base excess are being utilized for management and prognostication in trauma patients despite their inherent limitations. Recently, parathyroid hormone (PTH) showed better accuracy in predicting blood transfusion and mortality compared with lactate. This study compared the utility of lactate, base excess, and PTH as biomarkers in trauma resuscitation as well as outcome.

Methods: A prospective observational study was performed at a Level I trauma centre in consecutive adult patients presenting primarily with at least class III trauma haemorrhagic shock from January 2021 to December 2023. Eighty-two patients were included. The comparison was done based on resuscitation response, mortality and need for emergency surgical intervention. Most of them sustained blunt injuries, the mean age was (34.3 ± 12.6) years, and 80% were men. PTH measurement was added to the standard laboratory workup on presentation and subsequently during resuscitation. The categorical variables were analysed using Chi-square test whereas continuous variables were analysed with student t-test. The data were analysed using SPSS 30 software.

Results: Patients who were non-responders to initial resuscitation measures (28.0%) had significantly higher mean initial lactate levels compared with responders (5.9 ± 4.5 vs. 7.6 ± 4.3; p = 0.043). Base excess and PTH level difference were not statistically significant. No biomarkers were significantly different between patients needing emergency surgery in comparison to those who did not. Initial mean base excess levels were significantly high in the deceased group compared with survivors (-12.0 ± 7.4 vs. -8.5 ± 5.6; p = 0.071). At reassessment, all 3 biomarkers were significantly different between survivors and non-survivors.

Conclusion: Lactate, base excess, and PTH in isolation could not predict response and outcomes among trauma patients with haemorrhagic shock. Failure of these markers to normalize over time was associated with significantly higher need for blood product transfusion as well as mortality.

目的:乳酸和碱过量被用于创伤患者的管理和预后,尽管它们具有固有的局限性。近年来,甲状旁腺激素(PTH)在预测输血和死亡率方面比乳酸水平显示出更好的准确性。本研究比较了乳酸、碱性过剩和甲状旁腺激素作为生物标志物在创伤复苏和预后中的作用。方法:一项前瞻性观察性研究于2021年1月至2023年12月在一家一级创伤中心对主要表现为至少III级创伤出血性休克的连续成年患者进行了研究。纳入82例患者。根据复苏反应、死亡率和紧急手术干预的需要进行比较。以钝伤为主,平均年龄(34.3±12.6)岁,男性占80%。甲状旁腺激素的测量被添加到标准的实验室检查中,并随后在复苏期间进行。分类变量分析采用卡方检验,连续变量分析采用学生t检验。采用SPSS 30软件对数据进行分析。结果:对初始复苏措施无反应的患者(28.0%)的平均初始乳酸水平显著高于应答者(5.9±4.5比7.6±4.3;p = 0.043)。基数过剩与甲状旁腺素水平差异无统计学意义。与不需要紧急手术的患者相比,需要紧急手术的患者之间没有明显的生物标志物差异。与幸存者相比,死亡组的初始平均基础过量水平显著高(-12.0±7.4比-8.5±5.6;p = 0.071)。在重新评估时,所有3项生物标志物在幸存者和非幸存者之间均有显著差异。结论:乳酸、碱过量和甲状旁腺激素不能单独预测创伤患者出血性休克的反应和预后。随着时间的推移,这些标记物不能正常化与输血需求和死亡率的显著增加有关。
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引用次数: 0
Stigmasterol ameliorates neurological deficits and neuroinflammation in rats with traumatic brain injury by suppressing STAT3/NF-κB/LCN-2. 豆甾醇通过抑制STAT3/NF-κB/LCN-2改善创伤性脑损伤大鼠的神经功能缺损和神经炎症。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-01-02 DOI: 10.1016/j.cjtee.2025.05.003
Jing-Yuan Zhou, Li-Ming Tan, Zhen-Yu Nie, Bin Liu, Bing Wang
<p><strong>Purpose: </strong>TBI triggers intricate inflammatory processes that lead to secondary damage. Stig, a compound known for its cholesterol-lowering effects, demonstrates significant therapeutic potential, encompassing anti-cancer, antioxidant, and anti-atherosclerotic properties. It possesses an ability to penetrate the blood-brain barrier and accumulate in the brain, where it exerts potent anti-inflammatory, anti-apoptotic, and anti-oxidative stress properties, specifically in conditions impacting the central nervous system.</p><p><strong>Methods: </strong>This study is a basic research combining in vitro and in vivo experiments. The experimental subjects include BV2 microglia (a murine-derived microglial cell line) and HT22 neurons (a murine-derived hippocampal neuronal cell line), with 3 samples of Sprague-Dawley rats in each group. In vitro experiments involved stimulating BV2 mouse microglial cells with LPS and HT22 mouse neuronal cells with H<sub>2</sub>O<sub>2</sub>, followed by treatment with varying concentrations of Stig to assess its impact on pro-inflammatory cytokines, oxidative stress mediators, and LCN-2. In vivo, a TBI rat model was developed, and rats were arbitrarily split into Sham, TBI, TBI + normal saline, and TBI + Stig cohorts. Neurological function was evaluated using the modified neurological severity score for acute phase assessment, while cognitive abilities and spatial learning were assessed via the Morris water maze test. HE staining and Nissl staining were employed to observe neuronal death, and the wet-dry method was utilized to quantify brain water content. Levels of LCN-2, microglial polarization markers, and apoptotic markers were quantified by Western blot and immunofluorescence. Data were examined utilizing GraphPad Prism 9.0 and SPSS 26.0 software. Continuous variables were expressed as mean ± SD. Normality of the data was evaluated utilizing the Shapiro-Wilk test. For normally distributed continuous variables between 2 cohorts, an independent samples t-test was employed. When comparing more than 2 cohorts, a one-way ANOVA was performed. Non-normally distributed data were denoted by the median (Q<sub>1</sub>, Q<sub>3</sub>). The Mann-Whitney U test was applied to compare variables not following a normal distribution. The Spearman correlation test was utilized to assess links between variables. Statistical significance was set as p < 0.05.</p><p><strong>Results: </strong>In vivo treatment with Stig ameliorated neurological dysfunction, brain edema, and neuronal apoptosis in TBI rats while enhancing both memory and learning performance. Stig reduced microglial activation and inflammatory responses in TBI by inhibiting the STAT3/NF-κB pathway and downregulating LCN-2 expression. Additionally, Stig markedly attenuated inflammation in LPS-stimulated microglial cells and reduced neuronal apoptosis and oxidative stress in H₂O₂-treated HT22 cells. Moreover, it effectively suppressed the activation of the STA
目的:脑外伤触发复杂的炎症过程,导致继发性损伤。Stig是一种以其降胆固醇作用而闻名的化合物,具有显著的治疗潜力,包括抗癌、抗氧化和抗动脉粥样硬化的特性。它具有穿透血脑屏障并在大脑中积累的能力,在那里它具有有效的抗炎,抗细胞凋亡和抗氧化应激特性,特别是在影响中枢神经系统的条件下。方法:本研究为体外实验与体内实验相结合的基础研究。实验对象为BV2小胶质细胞(鼠源性小胶质细胞系)和HT22神经元(鼠源性海马神经元细胞系),每组3只Sprague-Dawley大鼠。体外实验包括用LPS刺激BV2小鼠小胶质细胞和用H2O2刺激HT22小鼠神经元细胞,然后用不同浓度的Stig处理,以评估其对促炎细胞因子、氧化应激介质和LCN-2的影响。在体内,建立TBI大鼠模型,将大鼠随机分为Sham、TBI、TBI +生理盐水和TBI + Stig组。神经功能评估采用改良神经严重程度评分法进行急性期评估,认知能力和空间学习通过Morris水迷宫测试进行评估。采用HE染色、尼氏染色观察神经元死亡情况,采用干湿法定量脑含水量。Western blot和免疫荧光法检测LCN-2、小胶质细胞极化标记物和凋亡标记物的表达。采用GraphPad Prism 9.0和SPSS 26.0软件进行数据分析。连续变量用mean±SD表示。使用Shapiro-Wilk检验评估数据的正态性。对于2个队列间正态分布的连续变量,采用独立样本t检验。当比较超过2个队列时,进行单因素方差分析。非正态分布数据用中位数表示(Q1, Q3)。Mann-Whitney U检验用于比较不服从正态分布的变量。Spearman相关检验用于评估变量之间的联系。p < 0.05为差异有统计学意义。结果:Stig在体内可改善脑外伤大鼠的神经功能障碍、脑水肿和神经元凋亡,同时提高记忆和学习能力。Stig通过抑制STAT3/NF-κB通路和下调LCN-2表达,降低TBI小胶质细胞激活和炎症反应。此外,Stig显著减轻lps刺激的小胶质细胞的炎症,减少h2o2处理的HT22细胞的神经元凋亡和氧化应激。有效抑制LPS或H₂O₂诱导的STAT3/NF-κB/LCN-2信号级联的激活。结论:Stig通过抑制STAT3/NF-κB/LCN-2信号级联减轻神经炎症和神经元细胞死亡,在大鼠TBI模型中具有神经保护作用。
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引用次数: 0
Resuscitative endovascular balloon occlusion of the aorta in trauma patients: Past, present, and future 创伤患者主动脉血管内球囊闭塞的复苏:过去,现在和未来。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-01-01 DOI: 10.1016/j.cjtee.2025.10.003
Yong Fu , Wei Huang , Xin-jie Luo , Yong Luo , Lei Li , Wenjie Liu , Demetrios Demetriades
Resuscitative endovascular balloon occlusion of the aorta (REBOA) has emerged as a critical intervention for managing severe hemorrhagic shock in trauma patients. By temporarily occluding the aorta, REBOA aims to stabilize hemodynamics and prevent cardiovascular collapse until definitive hemorrhage control can be achieved. However, the clinical efficacy and optimal use of REBOA remain subjects of ongoing debate. This narrative review synthesizes the latest evidence on clinical outcomes, complications, and patient selection to provide a comprehensive assessment of REBOA's role in trauma resuscitation. This review is based on a selective analysis of the current literature, including clinical studies, randomized controlled trials, and meta-analyses, to evaluate the benefits and risks associated with REBOA in trauma settings. While REBOA technology has advanced significantly and its use has expanded across trauma centers, evidence-based guidelines for its application remain limited. The optimal indications and target populations for REBOA have yet to be clearly defined. Recent studies, including the only randomized controlled trial on REBOA to date, suggest that its use in hemodynamically unstable patients does not confer a mortality benefit and may even increase mortality compared to standard care alone. Furthermore, REBOA is associated with substantial risks, including ischemia-reperfusion injury, acute kidney injury, arterial injury, arterial embolism, limb ischemia, and even amputations. These complications highlight the need for careful patient selection and procedural refinement. Current evidence does not support the routine use of REBOA in trauma patients with hemorrhagic shock. Further research is essential to identify specific subpopulations that may benefit from this intervention and to optimize its application to maximize survival while minimizing complications. Until more robust data are available, REBOA should be employed judiciously, with careful consideration of its risks and benefits in individual cases.
目的:复苏血管内球囊阻塞主动脉(REBOA)已成为处理创伤患者严重失血性休克的关键干预措施。通过暂时阻塞主动脉,REBOA旨在稳定血流动力学,防止心血管衰竭,直到最终出血控制可以实现。然而,REBOA的临床疗效和最佳使用仍然是持续争论的主题。这篇叙述性综述综合了临床结果、并发症和患者选择的最新证据,以提供REBOA在创伤复苏中的作用的综合评估。方法:本综述基于对现有文献的选择性分析,包括临床研究、随机对照试验和荟萃分析,以评估创伤情况下REBOA的获益和风险。结果:虽然REBOA技术取得了显著的进步,并且在创伤中心的应用范围也得到了扩展,但其应用的循证指南仍然有限。REBOA的最佳适应症和目标人群尚未明确界定。最近的研究,包括迄今为止唯一一项关于REBOA的随机对照试验,表明在血液动力学不稳定的患者中使用REBOA并不会降低死亡率,甚至可能比单独使用标准治疗增加死亡率。此外,REBOA存在大量风险,包括缺血再灌注损伤、急性肾损伤、动脉损伤、动脉栓塞、肢体缺血甚至截肢。这些并发症强调了仔细选择患者和完善手术程序的必要性。结论:目前的证据不支持REBOA在创伤失血性休克患者中的常规应用。进一步的研究是必要的,以确定可能从这种干预中受益的特定亚群,并优化其应用,以最大限度地提高生存率,同时减少并发症。在获得更可靠的数据之前,应谨慎使用REBOA,并在个别情况下仔细考虑其风险和益处。
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引用次数: 0
Pyogenic flexor tenosynovitis: A current problem of hand surgery 化脓性屈肌腱滑膜炎:当前手外科的一个问题。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-01-01 DOI: 10.1016/j.cjtee.2024.10.008
Konstantin Lipatov , Arthur Asatryan , George Melkonyan , Aleksandr D. Kazantcev , Ekaterina Solov’eva , Irina Gorbacheva , Alexander S. Vorotyntsev , Andrey Y. Emelyanov

Purpose

Pyogenic flexor tenosynovitis is one of the most severe purulent diseases of the hand and is characterized by a high level of development of stiffness and contractures.

Methods

This is a retrospective study conducted on patients hospitalized in our center in 2022. Patients diagnosed with pyogenic flexor tenosynovitis, aged from 18 to 90 years were included. Exclusion criteria are pregnancy or breastfeeding, concomitant oncological diseases, and collagen diseases. All patients were operated on urgently. Debridement, drainage and irrigation were performed. On the 4th−5th day after the operation, when the inflammation subsided, rehabilitation began. The long-term outcome was assessed throughout 3−12 months after discharge and was based on the restoration of the volume of active movements. The results are assessed according to the total active motion scale. Continuous variables were presented as median (Q1, Q3), and were compared using the Mann-Whitney U test. Categorical variables were expressed as n (%), and comparisons were made between the 3 groups using the Spearman's rank correlation coefficient. Statistical significance was defined as a 2-sided p < 0.05.

Results

The results of the examination and treatment of 60 patients were analyzed. The frequency of pyogenic flexor tenosynovitis was 5.3% among all patients with purulent diseases of the hand during this period. Tendon necrosis was noted in 8 (13.3%) cases. Surgical treatment in 37 (61.7%) patients was completed with drainage and primary suture. The rest of the patients (23, 38.3%) underwent repeated debridement, which ended in 10 (16.7%) cases with the imposition of secondary sutures. The best recovery of function was noted in cases of maintaining the viability of the tendon.

Conclusions

Timely diagnosis and provision of comprehensive surgical care for patients with pyogenic flexor tenosynovitis in combination with early rehabilitation should be considered the key to successful treatment of this complex category of patients.
目的:化脓性屈肌腱滑膜炎是手部最严重的化脓性疾病之一,其特点是高度僵硬和挛缩。方法:对我院2022年住院患者进行回顾性研究。诊断为化脓性屈肌腱滑膜炎的患者,年龄从18岁到90岁不等。排除标准为怀孕或哺乳、伴发肿瘤疾病和胶原蛋白疾病。所有病人都接受了紧急手术。进行清创、引流和冲洗。术后第4 ~ 5天,炎症消退,开始康复治疗。出院后3-12个月评估长期结果,并以活动活动量的恢复为基础。根据总主动运动量表对结果进行评估。连续变量表示为中位数(Q1, Q3),并使用Mann-Whitney U检验进行比较。分类变量用n(%)表示,3组间比较采用Spearman等级相关系数。统计意义定义为双侧p结果:分析60例患者的检查和治疗结果。在此期间所有手部化脓性疾病患者中,化脓性屈肌腱滑膜炎的发生率为5.3%。肌腱坏死8例(13.3%)。手术治疗37例(61.7%)完成引流和一期缝合。其余23例(38.3%)进行了多次清创,其中10例(16.7%)进行了二次缝合。在维持肌腱活力的情况下,功能恢复最好。结论:对化脓性屈肌腱滑膜炎患者及时诊断并提供全面的外科护理,结合早期康复治疗是成功治疗这类复杂患者的关键。
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引用次数: 0
Advances in rhabdomyolysis: A review of pathogenesis, diagnosis, and treatment 横纹肌溶解的研究进展:发病机制、诊断和治疗的综述。
IF 1.9 4区 医学 Q2 ORTHOPEDICS Pub Date : 2026-01-01 DOI: 10.1016/j.cjtee.2024.10.005
Bo-Fan Yang , Duo Li , Chun-Li Liu , Yu Luo , Jie Shi , Xiao-Qin Guo , Hao-Jun Fan , Qi Lyu
Rhabdomyolysis (RM) is a multifactorial clinical syndrome characterized by the disintegration and necrosis of muscle tissue, leading to the release of cellular contents into the circulation. One of the most severe complications of RM is acute kidney injury, with a mortality rate of 20%–50%. Early and timely diagnosis is the key to improving the prognosis of patients with RM. The etiology of RM is complex and associated with various trauma drugs, medications, and hereditary diseases, and the clinical symptoms are nonspecific. Therefore, its diagnosis highly relies on the doctor's experience and the level of medical equipment. However, RM often occurs in situations with limited medical resources, such as natural disasters, battlefields, and large-scale traffic accidents. In these scenarios, the varying levels of expertise among rescue personnel can lead to delays in diagnosis and treatment, thereby increasing the risk of mortality. This article provides a comprehensive review of the etiology, pathogenesis, complications, diagnostic, and treatment methods of RM. It also aims to offer new perspectives on the diagnosis and prognosis of RM by integrating machine learning and artificial intelligence. It is believed that this article can help pre-hospital rescuers and in-hospital doctors have a comprehensive understanding of RM to improve the patients' outcomes and overcome the challenges.
横纹肌溶解(Rhabdomyolysis, RM)是一种多因素临床综合征,其特征是肌肉组织解体和坏死,导致细胞内容物释放到循环中。RM最严重的并发症之一是急性肾损伤,死亡率为20%-50%。早期及时诊断是改善RM患者预后的关键。RM病因复杂,与各种创伤、药物、用药、遗传性疾病有关,临床症状无特异性。因此,其诊断高度依赖于医生的经验和医疗设备水平。然而,RM经常发生在医疗资源有限的情况下,如自然灾害、战场、大规模交通事故等。在这些情况下,救援人员的不同专业水平可能导致诊断和治疗的延误,从而增加死亡的风险。本文就该病的病因、发病机制、并发症、诊断及治疗方法作一综述。通过机器学习和人工智能的结合,为RM的诊断和预后提供新的视角。相信本文可以帮助院前救援人员和院内医生对RM有一个全面的了解,以改善患者的预后,克服挑战。
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引用次数: 0
期刊
Chinese Journal of Traumatology
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