The Construction of a Library of Nanozyme with High Nitrogen Content for Efficient Antibacterial Applications

IF 13 2区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY Small Pub Date : 2025-03-15 DOI:10.1002/smll.202500558
Chen Wang, Kui Yang, Tianyi Li, Lingshan Jia, Hongyuan Yan, Jia Wen
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Abstract

High catalytic efficiency is persistently pursued to generate high‐performance nanozymes. Metal elements are active centers where metal–organic frameworks (MOFs) play a catalytic role. In this work, a library of MOFs‐derived nanozyme is constructed based on metal salts and 1H‐1,2,3‐triazole (MET). Triazole has three N atoms; the intrinsic high N content is beneficial to improve the affinity of substrate H2O2. Meanwhile, different kinds of metals can be introduced by changing the metal salts, through which bimetallic or trimetallic MOFs can be constructed. Amongst various single–, bi‐, or trimetallic MET nanozymes, MET‐Fe1Zn0.5 nanozyme exhibits the best peroxidase (POD)‐like activity. The results demonstrate that the introduction of Zn accelerates electron transfer and promotes the conversion of Fe3+ to Fe2+ in MET‐Fe1Zn0.5 nanozyme, thus enhancing the POD‐like activity of MET‐Fe1Zn0.5 nanozyme. In particular, MET‐Fe1Zn0.5 nanozyme exhibits excellent antibacterial efficiency. A study on antibacterial mechanism indicates that MET‐Fe1Zn0.5 nanozyme has good adhesion to the bacterial membrane and can work in conjunction with reactive oxygen species, disrupting the oxidative phosphorylation, DNA replication, and biosynthesis of essential amino acids and cofactors within bacteria, leading to membrane damage and, eventually death of bacteria. These results suggest that a high N‐coordination number MET has great potential as a new‐generation nanozyme.
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来源期刊
Small
Small 工程技术-材料科学:综合
CiteScore
17.70
自引率
3.80%
发文量
1830
审稿时长
2.1 months
期刊介绍: Small serves as an exceptional platform for both experimental and theoretical studies in fundamental and applied interdisciplinary research at the nano- and microscale. The journal offers a compelling mix of peer-reviewed Research Articles, Reviews, Perspectives, and Comments. With a remarkable 2022 Journal Impact Factor of 13.3 (Journal Citation Reports from Clarivate Analytics, 2023), Small remains among the top multidisciplinary journals, covering a wide range of topics at the interface of materials science, chemistry, physics, engineering, medicine, and biology. Small's readership includes biochemists, biologists, biomedical scientists, chemists, engineers, information technologists, materials scientists, physicists, and theoreticians alike.
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