Wenyue Gong , Yiwen Wang , Haowen Zou , Yinghong Huang , Azi Shen , Qinghua Zhai , Kaiyu Shi , Rui Yan , Moxuan Song , Zhijian Yao , Qing Lu
{"title":"Choroid plexus enlargement correlates with cognitive impairment and brain atrophy in patients with mood disorders","authors":"Wenyue Gong , Yiwen Wang , Haowen Zou , Yinghong Huang , Azi Shen , Qinghua Zhai , Kaiyu Shi , Rui Yan , Moxuan Song , Zhijian Yao , Qing Lu","doi":"10.1016/j.jad.2025.03.047","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Patients with bipolar disorder (BD) and major depressive disorder (MDD) often exhibit cognitive impairments, with choroid plexus (ChP) volume linked to these deficits and cortical structures. However, the relationship between ChP volume, cognition, and brain morphology in mood disorders remains understudied. This study aimed to investigate these mechanisms.</div></div><div><h3>Method</h3><div>The study included 216 BD patients, 316 MDD patients, and 268 healthy controls who completed questionnaires, cognitive tests (e.g., the Symbol Digit Modalities Test (SDMT), the Verbal Fluency Test (VFT), the Chinese Revised Wechsler Memory Scale), and MRI scans. ChP volume, subcortical volume, and cortical thickness were measured, with group differences analyzed and correlations examined and compared.</div></div><div><h3>Results</h3><div>BD and MDD patients had significantly larger ChP volume than healthy controls, with no difference between patient groups. In both groups, ChP volume negatively correlated with subcortical volume (<em>r</em> = −0.021 ∼ −0.285, <em>q</em> < 0.05) and cortical thickness (<em>r</em> = −0.149 ∼ −0.317, <em>q</em> < 0.05). Furthermore, ChP volume negatively correlated with logical memory (<em>r</em> = −0.154 ∼ −0.161, <em>q</em> < 0.05) and positively with visual reproduction (<em>r</em> = −0.159, <em>q</em> = 0.043) in BD, while negatively correlated with the SDMT (<em>r</em> = −0.122 ∼ −0.152, <em>p</em> < 0.05) and VFT (<em>r</em> = −0.118, <em>p</em> = 0.015) in MDD. Associations between ChP volume and right precentral gyrus thickness and memory quotient differed between the two groups.</div></div><div><h3>Conclusion</h3><div>Enlarged ChP volume in mood disorders was associated with brain atrophy and cognitive deficits, suggesting it could serve as a marker for structural and cognitive changes.</div></div>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":"379 ","pages":"Pages 370-378"},"PeriodicalIF":4.9000,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of affective disorders","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165032725003830","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Patients with bipolar disorder (BD) and major depressive disorder (MDD) often exhibit cognitive impairments, with choroid plexus (ChP) volume linked to these deficits and cortical structures. However, the relationship between ChP volume, cognition, and brain morphology in mood disorders remains understudied. This study aimed to investigate these mechanisms.
Method
The study included 216 BD patients, 316 MDD patients, and 268 healthy controls who completed questionnaires, cognitive tests (e.g., the Symbol Digit Modalities Test (SDMT), the Verbal Fluency Test (VFT), the Chinese Revised Wechsler Memory Scale), and MRI scans. ChP volume, subcortical volume, and cortical thickness were measured, with group differences analyzed and correlations examined and compared.
Results
BD and MDD patients had significantly larger ChP volume than healthy controls, with no difference between patient groups. In both groups, ChP volume negatively correlated with subcortical volume (r = −0.021 ∼ −0.285, q < 0.05) and cortical thickness (r = −0.149 ∼ −0.317, q < 0.05). Furthermore, ChP volume negatively correlated with logical memory (r = −0.154 ∼ −0.161, q < 0.05) and positively with visual reproduction (r = −0.159, q = 0.043) in BD, while negatively correlated with the SDMT (r = −0.122 ∼ −0.152, p < 0.05) and VFT (r = −0.118, p = 0.015) in MDD. Associations between ChP volume and right precentral gyrus thickness and memory quotient differed between the two groups.
Conclusion
Enlarged ChP volume in mood disorders was associated with brain atrophy and cognitive deficits, suggesting it could serve as a marker for structural and cognitive changes.
期刊介绍:
The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.