Choroid plexus enlargement correlates with cognitive impairment and brain atrophy in patients with mood disorders

IF 4.9 2区 医学 Q1 CLINICAL NEUROLOGY Journal of affective disorders Pub Date : 2025-03-13 DOI:10.1016/j.jad.2025.03.047
Wenyue Gong , Yiwen Wang , Haowen Zou , Yinghong Huang , Azi Shen , Qinghua Zhai , Kaiyu Shi , Rui Yan , Moxuan Song , Zhijian Yao , Qing Lu
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Abstract

Background

Patients with bipolar disorder (BD) and major depressive disorder (MDD) often exhibit cognitive impairments, with choroid plexus (ChP) volume linked to these deficits and cortical structures. However, the relationship between ChP volume, cognition, and brain morphology in mood disorders remains understudied. This study aimed to investigate these mechanisms.

Method

The study included 216 BD patients, 316 MDD patients, and 268 healthy controls who completed questionnaires, cognitive tests (e.g., the Symbol Digit Modalities Test (SDMT), the Verbal Fluency Test (VFT), the Chinese Revised Wechsler Memory Scale), and MRI scans. ChP volume, subcortical volume, and cortical thickness were measured, with group differences analyzed and correlations examined and compared.

Results

BD and MDD patients had significantly larger ChP volume than healthy controls, with no difference between patient groups. In both groups, ChP volume negatively correlated with subcortical volume (r = −0.021 ∼ −0.285, q < 0.05) and cortical thickness (r = −0.149 ∼ −0.317, q < 0.05). Furthermore, ChP volume negatively correlated with logical memory (r = −0.154 ∼ −0.161, q < 0.05) and positively with visual reproduction (r = −0.159, q = 0.043) in BD, while negatively correlated with the SDMT (r = −0.122 ∼ −0.152, p < 0.05) and VFT (r = −0.118, p = 0.015) in MDD. Associations between ChP volume and right precentral gyrus thickness and memory quotient differed between the two groups.

Conclusion

Enlarged ChP volume in mood disorders was associated with brain atrophy and cognitive deficits, suggesting it could serve as a marker for structural and cognitive changes.
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来源期刊
Journal of affective disorders
Journal of affective disorders 医学-精神病学
CiteScore
10.90
自引率
6.10%
发文量
1319
审稿时长
9.3 weeks
期刊介绍: The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.
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