Hailin Ran , Hui Li , Danli Peng , Yiru Hou , Yongmei Jiang , Juxiang Kuang , Anjun Wang , Xin Zhang , Gang Wang
{"title":"Research progress on extraction of flavonoids with deep eutectic solvents from natural products","authors":"Hailin Ran , Hui Li , Danli Peng , Yiru Hou , Yongmei Jiang , Juxiang Kuang , Anjun Wang , Xin Zhang , Gang Wang","doi":"10.1016/j.molliq.2025.127356","DOIUrl":null,"url":null,"abstract":"<div><h3>Abstract</h3><div>Flavonoid compounds are abundant in natural products and have attracted enduring interest from medical researchers worldwide due to their diverse biological activities, which studies have demonstrated to provide therapeutic benefits for various conditions, including cardiovascular diseases, cancer, and nervous system disorders. Consequently, the extraction of flavonoids from natural sources has become a major research priority. This review provides an overview of the application of Deep eutectic solvents (DESs) in flavonoid extraction, along with key factors influencing extraction efficiency. Furthermore, this research progress on the mechanisms behind the recovery and extraction of flavonoids using DESs. The results of the study provide theoretical basis for the further development and utilization of flavonoids extraction by DESs.</div></div>","PeriodicalId":371,"journal":{"name":"Journal of Molecular Liquids","volume":"426 ","pages":"Article 127356"},"PeriodicalIF":5.3000,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Liquids","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167732225005239","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Flavonoid compounds are abundant in natural products and have attracted enduring interest from medical researchers worldwide due to their diverse biological activities, which studies have demonstrated to provide therapeutic benefits for various conditions, including cardiovascular diseases, cancer, and nervous system disorders. Consequently, the extraction of flavonoids from natural sources has become a major research priority. This review provides an overview of the application of Deep eutectic solvents (DESs) in flavonoid extraction, along with key factors influencing extraction efficiency. Furthermore, this research progress on the mechanisms behind the recovery and extraction of flavonoids using DESs. The results of the study provide theoretical basis for the further development and utilization of flavonoids extraction by DESs.
期刊介绍:
The journal includes papers in the following areas:
– Simple organic liquids and mixtures
– Ionic liquids
– Surfactant solutions (including micelles and vesicles) and liquid interfaces
– Colloidal solutions and nanoparticles
– Thermotropic and lyotropic liquid crystals
– Ferrofluids
– Water, aqueous solutions and other hydrogen-bonded liquids
– Lubricants, polymer solutions and melts
– Molten metals and salts
– Phase transitions and critical phenomena in liquids and confined fluids
– Self assembly in complex liquids.– Biomolecules in solution
The emphasis is on the molecular (or microscopic) understanding of particular liquids or liquid systems, especially concerning structure, dynamics and intermolecular forces. The experimental techniques used may include:
– Conventional spectroscopy (mid-IR and far-IR, Raman, NMR, etc.)
– Non-linear optics and time resolved spectroscopy (psec, fsec, asec, ISRS, etc.)
– Light scattering (Rayleigh, Brillouin, PCS, etc.)
– Dielectric relaxation
– X-ray and neutron scattering and diffraction.
Experimental studies, computer simulations (MD or MC) and analytical theory will be considered for publication; papers just reporting experimental results that do not contribute to the understanding of the fundamentals of molecular and ionic liquids will not be accepted. Only papers of a non-routine nature and advancing the field will be considered for publication.