The kinase CPK5 phosphorylates MICRORCHIDIA1 to promote broad-spectrum disease resistance.

IF 10 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Plant Cell Pub Date : 2025-03-14 DOI:10.1093/plcell/koaf051

Congcong Sun, Yongming Chen, Aifang Ma, Pan Wang, Yingying Song, Jiaxin Pan, Tingting Zhao, Zhipeng Tu, Xiangxiu Liang, Xiaodan Wang, Jun Fan, Guozhi Bi, Xiangzong Meng, Daolong Dou, Guangyuan Xu

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Abstract

In Arabidopsis (Arabidopsis thaliana), MICRORCHIDIA 1 (MORC1), a member of the MORC family of evolutionarily conserved GHKL-type ATPases, plays important roles in multiple layers of plant immunity. However, the molecular mechanism by which MORC1 regulates plant immunity remains obscure. Here, we report that the pathogen-responsive kinase CALCIUM-DEPENDENT PROTEIN KINASE 5 (CPK5) directly interacts with and phosphorylates MORC1, thereby promoting its stability and nuclear translocation. In the nucleus, MORC1 associates with the NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1)-TGACG-BINDING FACTOR (TGA) transcriptional complex to upregulate defense-responsive genes and promote plant resistance against several pathogens, such as the bacterial pathogen Pseudomonas syringae pv. tomato DC3000 and fungal pathogen Botrytis cinerea. Therefore, this study uncovers a MORC1-mediated immune signaling pathway, in which the CPK5-MORC1-NPR1-TGA module transduces Ca2+ signals, leading to the upregulation of defense genes involved in plant immunity.

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激酶 CPK5 磷酸化 MICRORCHIDIA1，促进广谱抗病性。

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来源期刊

Plant Cell 生物-生化与分子生物学

CiteScore

16.90

自引率

5.20%

发文量

337

审稿时长

2.4 months

期刊介绍： Title: Plant Cell Publisher: Published monthly by the American Society of Plant Biologists (ASPB) Produced by Sheridan Journal Services, Waterbury, VT History and Impact: Established in 1989 Within three years of publication, ranked first in impact among journals in plant sciences Maintains high standard of excellence Scope: Publishes novel research of special significance in plant biology Focus areas include cellular biology, molecular biology, biochemistry, genetics, development, and evolution Primary criteria: articles provide new insight of broad interest to plant biologists and are suitable for a wide audience Tenets: Publish the most exciting, cutting-edge research in plant cellular and molecular biology Provide rapid turnaround time for reviewing and publishing research papers Ensure highest quality reproduction of data Feature interactive format for commentaries, opinion pieces, and exchange of information in review articles, meeting reports, and insightful overviews.