Differentiation with electroencephalography microstate in temporal lobe epilepsy with and without cognitive decline

IF 2.3 3区医学 Q2 BEHAVIORAL SCIENCES Epilepsy & Behavior Pub Date : 2025-05-01 Epub Date: 2025-03-15 DOI:10.1016/j.yebeh.2025.110365

Lingxuan Lv , Nan Lin , Weifang Gao , Feifei Zhai , Jing Wang , Huanhuan Xiang , Xinshan Liu , Heyang Sun , Qiang Lu , Mengyang Wang , Qing Liu , Yicheng Zhu

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Abstract

Objective

Electroencephalography (EEG) microstate analysis is widely used in the study of various neurological and psychiatric disorders. We aim to assess whether EEG microstates are altered in TLE patients with and without cognitive decline.

Methods

This study included a total of 47 temporal lobe epilepsy (TLE) patients with or without cognitive decline and 14 healthy controls (HCs). All participants underwent 64-channel EEG monitoring. Two-minute epochs of preprocessed eye closed awake EEG data were extracted for microstate analysis. Participants were divided into groups based on intelligence quotient (IQ) scores assessed by the Wechsler Intelligence Scale: normal cognition group (n = 23, IQ ≥ 90) and abnormal cognition group (n = 24, IQ < 90). We conducted frequency spectral analysis on each frequency sub-bands (delta, 1–4 Hz; theta, 4–8 Hz; alpha, 8–12 Hz; beta, 12–30 Hz) of the three groups. Then the following microstate parameters were extracted for analysis over the full frequency band (1–30 Hz) and frequency sub-bands: duration, coverage, occurrence, and transition probability. Statistical analysis using multivariate analysis of variance (MANOVA) with Bonferroni correction (α = 0.0025).

Result

Microstate analysis in the beta sub-band revealed significant differences among groups. TLE patients with abnormal cognition showed increased occurrence of Map-D; significantly higher transition probabilities from Map-A, Map-B, and Map-C to Map-D; and distinct microstate characteristics compared to patients with normal cognition and HCs. In frequency spectral analysis, the power across all frequency sub-bands showed no significant differences among TLE patients with normal cognition, TLE patients with abnormal cognition, and HCs.

Conclusion

Beta sub-band EEG microstates, particularly Map-D characteristics, may serve as potential neurophysiological markers for cognitive decline in TLE patients.

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伴与不伴认知能力下降的颞叶癫痫的脑电图微态鉴别

目的脑电图（EEG）微状态分析广泛应用于各种神经和精神疾病的研究。我们的目的是评估脑电图微状态是否改变TLE患者有或没有认知能力下降。方法本研究共纳入47例伴有或不伴有认知能力下降的颞叶癫痫（TLE）患者和14例健康对照（hc）。所有参与者均接受64通道脑电图监测。提取经预处理的闭眼清醒脑电数据进行微态分析。根据韦氏智力量表评定的智商（IQ）得分将参与者分为正常认知组（n = 23, IQ≥90）和异常认知组(n = 24, IQ <；90)。我们对各频段进行频谱分析(delta, 1-4 Hz；θ, 4 - 8hz；alpha, 8-12 Hz；β， 12-30赫兹)。然后提取全频段（1 ~ 30 Hz）和子频段的微状态参数：持续时间、覆盖范围、发生频率和转移概率进行分析。统计分析采用Bonferroni校正的多变量方差分析（MANOVA）（α = 0.0025）。结果β子带微态分析显示各组间差异有统计学意义。认知异常的TLE患者Map-D发生率增高；从Map-A、Map-B和Map-C到Map-D的转换概率显著提高；与正常认知和hc患者相比，有明显的微观状态特征。在频谱分析中，认知正常的TLE患者、认知异常的TLE患者和hc患者各频段的功率均无显著差异。结论β亚带EEG微状态，特别是Map-D特征，可能是TLE患者认知能力下降的潜在神经生理指标。

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来源期刊

Epilepsy & Behavior 医学-行为科学

CiteScore

5.40

自引率

15.40%

发文量

385

审稿时长

43 days

期刊介绍： Epilepsy & Behavior is the fastest-growing international journal uniquely devoted to the rapid dissemination of the most current information available on the behavioral aspects of seizures and epilepsy. Epilepsy & Behavior presents original peer-reviewed articles based on laboratory and clinical research. Topics are drawn from a variety of fields, including clinical neurology, neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuropharmacology, and neuroimaging. From September 2012 Epilepsy & Behavior stopped accepting Case Reports for publication in the journal. From this date authors who submit to Epilepsy & Behavior will be offered a transfer or asked to resubmit their Case Reports to its new sister journal, Epilepsy & Behavior Case Reports.