Amphetamine use and mental health difficulties across adolescence and young adulthood: An integrative data analysis of four Australasian cohort studies.

IF 5.2 1区 医学 Q1 PSYCHIATRY Addiction Pub Date : 2025-03-15 DOI:10.1111/add.70033
Christopher J Greenwood, James Foulds, Rebecca McKetin, Stephanie R Aarsman, Delyse Hutchinson, Jessica Kerr, Jessica A Heerde, John W Toumbourou, Joseph M Boden, Tim Slade, Yvonne Bonomo, Primrose Letcher, Craig A Olsson
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Abstract

Background and aims: The use of amphetamines (including amphetamine and methamphetamine) has been consistently associated with mental health difficulties; however, the direction of potential causal relationships has not yet been established. This study aimed to assess the direction relationships between illicit amphetamine use and mental health difficulties across adolescence and young adulthood.

Design: Observational study of four population-level cohorts participating in the Monitoring Illicit Substance Use (MISUse) Consortium.

Setting: Australia and New Zealand.

Participants: A total of 7527 participants (51% female) were used: Christchurch Health and Development Study (n = 1056), Australian Temperament Project (n = 1644), Victorian Adolescent Health Cohort Study (n = 1943) and International Youth Development Study (n = 2884).

Measurements: Assessments were used to derive binary indicators of amphetamine use (≥monthly) and mental health difficulties during both adolescence (age 10-17 years) and young adulthood (age 18-30 years).

Findings: Associations were estimated as Risk Ratios (RRs) with 95% confidence internals (CIs) using G-computation procedures, while accounting for 15 potential confounding factors and interactions between exposure and both study cohort and participant sex. The risk of mental health difficulties in young adulthood was 21% greater (RR = 1.21, 95% CI = 1.04, 1.41) for those who reported monthly or more frequent amphetamine use in adolescence. The risk of monthly or higher amphetamine use in young adulthood was 19% greater (RR = 1.19, 95% CI = 0.99, 1.45) in those who reported mental health difficulties in adolescence. There was also some evidence to suggest that in males the strongest association was from amphetamine use to mental health difficulties (RR = 1.24, 95% CI = 0.95, 1.60), while in females the strongest association was from mental health difficulties to amphetamine use (RR = 1.33, 95% CI = 0.99, 1.78).

Conclusions: There appears to be a bidirectional association between monthly or more frequent amphetamine use and mental health difficulties from adolescence to young adulthood.

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来源期刊
Addiction
Addiction 医学-精神病学
CiteScore
10.80
自引率
6.70%
发文量
319
审稿时长
3 months
期刊介绍: Addiction publishes peer-reviewed research reports on pharmacological and behavioural addictions, bringing together research conducted within many different disciplines. Its goal is to serve international and interdisciplinary scientific and clinical communication, to strengthen links between science and policy, and to stimulate and enhance the quality of debate. We seek submissions that are not only technically competent but are also original and contain information or ideas of fresh interest to our international readership. We seek to serve low- and middle-income (LAMI) countries as well as more economically developed countries. Addiction’s scope spans human experimental, epidemiological, social science, historical, clinical and policy research relating to addiction, primarily but not exclusively in the areas of psychoactive substance use and/or gambling. In addition to original research, the journal features editorials, commentaries, reviews, letters, and book reviews.
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