Jiang Li MPH , Xiaoqing Xu MD , Yuefeng Yu MD , Ying Sun MD , Lingli Cai MD , Wenqi Shen MD , Bin Wang PhD , Xiao Tan PhD , Yingli Lu MD , Ningjian Wang MD
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引用次数: 0
Abstract
Background
The association of long-term weight change with atrial fibrillation (AF) risk remains controversial, and evidence for the effect of metabolic health transition on AF is limited.
Objective
The purpose of this study was to evaluate the effects of body mass index (BMI) change and transition in BMI–metabolic health status on AF.
Methods
We conducted a prospective cohort study within the UK Biobank. Metabolic health was defined as having at least 4 of the 6 metabolically healthy (MH) criteria including blood pressure, C-reactive protein, triacylglycerols, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and glycated hemoglobin.
Results
Of the 490,969 participants initially included for baseline BMI analysis, 33,297 AF cases were observed during a median follow-up of 14.0 years. Overweight (hazard ratio [HR] 1.12; 95% confidence interval [CI] 1.09–1.15) and obesity (1.74; 1.68–1.79) significantly increased the risk of AF. A BMI loss of >2% per year was associated with a lower risk of AF (0.75; 0.57–0.99), especially transitioning from obesity to overweight (0.74; 0.54–1.02), though without statistical significance. Compared with MH-normal weight, the HRs for MH-obesity and metabolically unhealthy (MU)–obesity were 1.74 (1.67–1.81) and 1.76 (1.69–1.83), respectively. The transition from MH-overweight/obesity to MU-overweight/obesity increased the risk of AF (1.35; 0.97–1.88).
Conclusion
A BMI decrease of >2% per year was associated with a lower risk of AF, particularly in those changing from obesity to overweight. The transition from MH-overweight/obesity to MU-overweight/obesity increased the risk of AF. Weight management and maintenance of metabolic health should be recommended for primary prevention of AF.
期刊介绍：
HeartRhythm, the official Journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, is a unique journal for fundamental discovery and clinical applicability.
HeartRhythm integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community.
The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal health care policies and standards.
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