Engineering the Hierarchical Porosity of Granular Hydrogel Scaffolds Using Porous Microgels to Improve Cell Recruitment and Tissue Integration (Adv. Funct. Mater. 12/2025)
Alexander Kedzierski, Sina Kheirabadi, Arian Jaberi, Zaman Ataie, Catherine L. Mojazza, Marisa L. Williamson, Anton M. Hjaltason, Aneesh Risbud, Yuanhui Xiang, Amir Sheikhi
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Abstract
Hydrogel Scaffolds
In article number 2417704, Amir Sheikhi and co-workers develop a new class of granular hydrogel scaffolds with hierarchical porosity by fabricating and covalently assembling gelatin methacryloyl (GelMA) porous microgels. These scaffolds feature a significantly higher void fraction compared with those made from nonporous microgels, thereby enhancing cell recruitment and tissue integration. This research may pave the way for developing hierarchically porous translational granular biomaterials, aiming to accelerate endogenous tissue repair.
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