Frontispiz: Ultrasensitive Characterization of Native Bacterial Biofilms via Dynamic Nuclear Polarization-Enhanced Solid-State NMR

Chang-Hyeock Byeon, Ted Kinney, Dr. Hakan Saricayir, Kasper Holst Hansen, Dr. Faith J. Scott, Sadhana Srinivasa, Meghan K. Wells, Dr. Frederic Mentink-Vigier, Prof. Wook Kim, Prof. Ümit Akbey
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Abstract

Ultrasensitive characterization of native bacterial biofilm: A high-sensitivity dynamic nuclear polarization (DNP) enhanced solid-state NMR method illuminates the composition of intact native bacterial biofilm. The DNP sensitivity boost (~75-fold) allows observing NMR signals of biofilms composed of bacteria and extracellular matrix at natural abundance, shown here for Pseudomonas. Chemical identification quantifies the biofilm components, as reported by Ümit Akbey et^^al. in their Research Article (e202418146).

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Angewandte Chemie
Angewandte Chemie 化学科学, 有机化学, 有机合成
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Frontispiz: Ultrasensitive Characterization of Native Bacterial Biofilms via Dynamic Nuclear Polarization-Enhanced Solid-State NMR Titelbild: Alcohol Self-Aggregation: the Preferred Configurations of the Ethanol Trimer (Angew. Chem. 12/2025) Frontispiz: Improving Electrocatalytic CO2 Reduction over Iron Tetraphenylporphyrin with Triethanolamine as a CO2 Shuttle Frontispiz: Orthogonal-Group-Controlled Site-Selective I-Branching of Poly-N-acetyllactosamine Chains Reveals Unique Binding Specificities of Proteins towards I-Antigens Frontispiz: Contrasting Mechanochromic Luminescence of Enantiopure and Racemic Pyrenylprolinamides: Elucidating Solid-State Excimer Orientation by Circularly Polarized Luminescence
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