Functional magnetic resonance imaging in prurigo nodularis: A call to study neural sensitization phenomena

IF 3.5 4区医学 Q2 DERMATOLOGY Clinics in dermatology Pub Date : 2025-09-01 Epub Date: 2025-03-14 DOI:10.1016/j.clindermatol.2025.03.005

Xuanyu Zhao MD , Jannis M. Mueller MD , Simon M. Mueller MD

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Abstract

Prurigo nodularis is a chronic pruritic, inflammatory skin condition characterized by nodular skin lesions in a typical distribution pattern caused by various dermatologic and/or nondermatologic conditions. In recent years, significant advances have been made in the understanding of the cutaneous pathophysiology of prurigo nodularis, resulting in novel treatment options such as interleukin-4, -13, -17, and -31 or Janus kinase inhibitors. Many aspects of the neurophysiology are largely unknown, including the processing in the central structural and functional network involved in prurigo nodularis. Functional neuroimaging allows noninvasive assessment of brain function and structure. Due to its high spatial resolution and temporal precision, functional magnetic resonance imaging has proven to be a suitable method for exploring neural mechanisms and assessing pharmacologic effects in dermatologic research. In this systematic review, the current knowledge of functional magnetic resonance imaging in the context of prurigo nodularis and its centrally active treatment options is summarized.

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结节性痒疹的功能磁共振成像：系统综述。

结节性痒疹（PN）是一种慢性瘙痒性炎症性皮肤病，其特征是由各种皮肤病和/或非皮肤病引起的典型分布模式的结节性皮肤病变。近年来，在对PN的皮肤病理生理的理解方面取得了重大进展，导致了新的治疗选择，如白介素-4、-13、-17、-31或Januskinase抑制剂。然而，神经生理学的许多方面在很大程度上是未知的，包括涉及PN的中央结构和功能网络的处理。功能性神经成像允许对大脑功能和结构进行无创评估。功能磁共振成像（functional magnetic resonance imaging, fMRI）由于具有较高的空间分辨率和时间精度，已被证明是皮肤病学研究中探索神经机制和评估药理作用的合适方法。在这篇系统的综述中，总结了目前功能性磁共振成像在PN及其核心治疗方案方面的知识。

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来源期刊

Clinics in dermatology 医学-皮肤病学

CiteScore

4.60

自引率

7.40%

发文量

106

审稿时长

3 days

期刊介绍： Clinics in Dermatology brings you the most practical and comprehensive information on the treatment and care of skin disorders. Each issue features a Guest Editor and is devoted to a single timely topic relating to clinical dermatology. Clinics in Dermatology provides information that is... • Clinically oriented -- from evaluation to treatment, Clinics in Dermatology covers what is most relevant to you in your practice. • Authoritative -- world-renowned experts in the field assure the high-quality and currency of each issue by reporting on their areas of expertise. • Well-illustrated -- each issue is complete with photos, drawings and diagrams to illustrate points and demonstrate techniques.