Huili Li , Xiaoxue Li , Yi Liu , Ronglian Xing , Hongxia Zhang , Wenguang Jia , Lihong Chen , Rui Li , Zhen Yu , Zhihong Tang
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引用次数: 0
Abstract
Frequent red tide outbreaks pose a serious threat to biodiversity and the safety of aquatic ecosystems. Bacillamides showed algicidal activity against algae. However, the low natural concentrations and their structural complexity hinder development of these molecules. Inspired by the natrual algicide Bacillamide A, a series of thiourea derivatives were synthesized. Bacillamide A derivative (3B) showed excellent algicidal activity against S. costatum (EC50 = 0.52 μg/mL) and P. minimum (EC50 = 2.99 μg/mL), respectively. In addition, it has low toxicity to mammals and is less toxic than copper sulfate. 3B treatment resulted in loss of algal cell integrity. It also decreased the Chlorophyll a content and Fv/fm of algal cells, while increasing the levels of malondialdehyde content, superoxide dismutase, and reactive oxygen. 3B also induced expression of the photosynthetic genes, including psaB, psbB, as well as the antioxidant genes SOD2 and CAT. This study demonstrates that Bacillamide A derivatives could provide a safer alternative for red tide algal management.
期刊介绍:
Pesticide Biochemistry and Physiology publishes original scientific articles pertaining to the mode of action of plant protection agents such as insecticides, fungicides, herbicides, and similar compounds, including nonlethal pest control agents, biosynthesis of pheromones, hormones, and plant resistance agents. Manuscripts may include a biochemical, physiological, or molecular study for an understanding of comparative toxicology or selective toxicity of both target and nontarget organisms. Particular interest will be given to studies on the molecular biology of pest control, toxicology, and pesticide resistance.
Research Areas Emphasized Include the Biochemistry and Physiology of:
• Comparative toxicity
• Mode of action
• Pathophysiology
• Plant growth regulators
• Resistance
• Other effects of pesticides on both parasites and hosts.