Case Report: Concurrent Babesiosis and GCA/PMR

Abstract

Background

Babesiosis is a tick-transmitted illness caused by intraerythrocytic protozoa of the genus babesia. The severity of babesiosis ranges from asymptomatic infection to fatal disease. Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are common interrelated inflammatory disorders that almost occur in people aged over 50 years. This report presents the first case of concurrent babesiosis and GCA/PMR in an old person.

Case Presentation

A 63-year-old man was admitted to the hospital with a 1-month history of fevers, accompanied by headache, muscle pain and fatigue. Laboratory tests revealed hemolytic anemia, with elevated C-reactive protein, serum IL-6 and erythrocyte sedimentation rate. FDG positron-emission tomography-computed tomography (PET-CT) scan exhibited increased uptake in aortic wall, multiple medium-to-large arteries and soft tissues. A blood smear revealed Babesia microti intracellular ring forms. Babesia microti infection was further confirmed by polymerase chain reaction (PCR) test. This patient was diagnosed as concurrent babesiosis and GCA/PMR. He was treated with glucocorticoid and antimicrobial therapy.

Conclusions

Concurrent babesiosis and GCA/PMR is rare. Further studies are needed to understand the mechanism of interaction between babesiosis and human immune system.