Case Report: Concurrent Babesiosis and GCA/PMR

IF 2.7 4区医学 Q3 IMMUNOLOGY Immunity, Inflammation and Disease Pub Date : 2025-03-19 DOI:10.1002/iid3.70182

Xiaolin Wang, Haohua Huang, Lichang Chen, Simin Guo, Qi-Ming Gong

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Abstract

Background

Babesiosis is a tick-transmitted illness caused by intraerythrocytic protozoa of the genus babesia. The severity of babesiosis ranges from asymptomatic infection to fatal disease. Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are common interrelated inflammatory disorders that almost occur in people aged over 50 years. This report presents the first case of concurrent babesiosis and GCA/PMR in an old person.

Case Presentation

A 63-year-old man was admitted to the hospital with a 1-month history of fevers, accompanied by headache, muscle pain and fatigue. Laboratory tests revealed hemolytic anemia, with elevated C-reactive protein, serum IL-6 and erythrocyte sedimentation rate. FDG positron-emission tomography-computed tomography (PET-CT) scan exhibited increased uptake in aortic wall, multiple medium-to-large arteries and soft tissues. A blood smear revealed Babesia microti intracellular ring forms. Babesia microti infection was further confirmed by polymerase chain reaction (PCR) test. This patient was diagnosed as concurrent babesiosis and GCA/PMR. He was treated with glucocorticoid and antimicrobial therapy.

Conclusions

Concurrent babesiosis and GCA/PMR is rare. Further studies are needed to understand the mechanism of interaction between babesiosis and human immune system.

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病例报告：并发巴贝斯虫病和GCA/PMR

巴贝斯虫病是一种由巴贝斯虫属红细胞原生动物引起的蜱传疾病。巴贝斯虫病的严重程度从无症状感染到致命疾病不等。巨细胞动脉炎（GCA）和风湿性多肌痛（PMR）是常见的相关炎症性疾病，几乎发生在50岁以上的人群中。本报告提出了第一例并发巴贝斯虫病和GCA/PMR的老年人。63岁男性，发热1个月，伴有头痛、肌肉疼痛和疲劳入院。实验室检查显示溶血性贫血，c反应蛋白、血清IL-6和红细胞沉降率升高。FDG正电子发射断层扫描-计算机断层扫描（PET-CT）显示主动脉壁、多条中大动脉和软组织摄取增加。血液涂片显示微巴贝斯虫细胞内环状。聚合酶链反应（PCR）进一步证实微巴贝虫感染。该患者被诊断为并发巴贝斯虫病和GCA/PMR。患者接受糖皮质激素和抗菌药物治疗。结论同时发生巴贝斯虫病和GCA/PMR是罕见的。巴贝斯虫病与人体免疫系统相互作用的机制有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology