{"title":"A new sesterterpenoid with <i>β</i>-glucuronidase inhibitory activity from the <i>Cordyceps</i>-colonising fungus <i>Aspergillus versicolour</i> ZJUTE2.","authors":"Youmin Ying, Yixian Qiu, Jing Tang, Yuhao Lin, Sha Xu, Jiayue Ni, Yun Zhang, Cuiping Tong, Wei Mao","doi":"10.1080/14786419.2025.2481477","DOIUrl":null,"url":null,"abstract":"<p><p>A new sesterterpenoid versicolorin A (<b>1</b>) and five known compounds <b>2</b>-<b>6</b> were isolated from a <i>Cordyceps</i>-colonising fungus <i>Aspergillus versicolour</i> ZJUTE2 cultured on soybean meal. The planar structure of <b>1</b> was determined by 1D, 2D NMR and HR-ESI-MS. The stereochemistry of <b>1</b> was established by NOESY experiment, quantum chemical calculation of <sup>13</sup>C NMR combined with DP4+ probability analysis, and comparison of the optical rotations. Compound <b>1</b> exhibited comparable <i>in vitro β</i>-glucuronidase inhibitory activity (IC<sub>50</sub> = 49.82 ± 1.21 µM) with D-saccharicacid 1,4-lactone (IC<sub>50</sub> = 57.35 ± 0.78 µM).</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.6000,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2481477","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
A new sesterterpenoid versicolorin A (1) and five known compounds 2-6 were isolated from a Cordyceps-colonising fungus Aspergillus versicolour ZJUTE2 cultured on soybean meal. The planar structure of 1 was determined by 1D, 2D NMR and HR-ESI-MS. The stereochemistry of 1 was established by NOESY experiment, quantum chemical calculation of 13C NMR combined with DP4+ probability analysis, and comparison of the optical rotations. Compound 1 exhibited comparable in vitro β-glucuronidase inhibitory activity (IC50 = 49.82 ± 1.21 µM) with D-saccharicacid 1,4-lactone (IC50 = 57.35 ± 0.78 µM).
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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