William Lee, Angelica Zamudio-Ochoa, Gina Buchel, Petar Podlesniy, Nuria Marti Gutierrez, Aleksei Mikhalchenko, Ramon Trullas, Shoukhrat Mitalipov, Dmitry Temiakov
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引用次数: 0
Abstract
replying to M. Alexeyev & Y. Bai Nature Genetics https://doi.org/10.1038/s41588-025-02149-7 (2025)
The dogma of uniparental inheritance of mitochondrial DNA (mtDNA) represents a fascinating aspect of genetics and the evolution of all living organisms. The processes underlying this trait involve molecular mechanisms that act before and after oocyte fertilization. The former involves elimination of mtDNA during spermatogenesis, the process of sperm cell maturation1,2,3. Post-fertilization mechanisms include removal of sperm mitochondria through autophagy and ubiquitin-mediated proteolysis after the cell penetrates an oocyte4,5.
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