A cross-sectional study: Relationship between serum oxidative stress levels and arteriovenous fistula maturation in maintenance dialysis patients.

IF 1.6 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Open Medicine Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI:10.1515/med-2025-1149

Mian Wang, JiHong Lian, Bin Kuang, ChaoHui Zhang, MingHui Zhang

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Abstract

Objective: This study was to investigate the relationship between serum superoxide dismutase (SOD) and malondialdehyde (MDA) and arteriovenous fistula (AVF) maturation in maintenance hemodialysis (MHD) patients.

Methods: A total of 120 MHD patients were divided into a maturation group (72 patients) and a maturation failure group (48 patients). General information and ultrasound data were collected and venous blood was drawn for routine blood tests. General data and serum SOD and MDA were compared. Independent variables with statistically significant (P < 0.05) differences in univariate analysis were included in multivariate logistic regression. Serum SOD and MDA in predicting maturation failure of AVF were analyzed using receiver operating characteristic curves.

Results: The internal diameter of the cephalic vein, internal diameter of the cephalic vein after tourniquet binding, internal diameter of the radial artery, and serum SOD level were lower and serum MDA level was higher in the maturation failure group. Reduced SOD and elevated MDA were independent risk factors for maturation failure of AVF. The area under the curve (AUC) for serum SOD and MDA was 0.68 each. When combined, their AUC for predicting AVF maturation failure was 0.79.

Conclusion: Reduced serum SOD and increased MDA are risk factors affecting AVF maturation in MHD patients.

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横断面研究：维持透析患者血清氧化应激水平与动静脉瘘成熟的关系。

目的：探讨维持性血液透析（MHD）患者血清超氧化物歧化酶（SOD）、丙二醛（MDA）与动静脉瘘（AVF）成熟的关系。方法：120例MHD患者分为成熟组（72例）和成熟衰竭组（48例）。收集一般资料和超声资料，抽取静脉血进行血常规检查。一般数据与血清SOD、MDA进行比较。多因素logistic回归纳入单因素分析中差异有统计学意义（P < 0.05）的自变量。采用受试者工作特征曲线分析血清SOD、MDA对AVF成熟衰竭的预测作用。结果：成熟衰竭组头静脉内径、止血带结扎后头静脉内径、桡动脉内径、血清SOD水平较低，血清MDA水平较高。SOD降低和MDA升高是AVF成熟衰竭的独立危险因素。血清SOD和MDA的曲线下面积（AUC）均为0.68。两者综合起来，预测AVF成熟失败的AUC为0.79。结论：血清SOD降低、MDA升高是影响MHD患者AVF成熟的危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Open Medicine Medicine-General Medicine

CiteScore

3.00

自引率

0.00%

发文量

153

审稿时长

20 weeks

期刊介绍： Open Medicine is an open access journal that provides users with free, instant, and continued access to all content worldwide. The primary goal of the journal has always been a focus on maintaining the high quality of its published content. Its mission is to facilitate the exchange of ideas between medical science researchers from different countries. Papers connected to all fields of medicine and public health are welcomed. Open Medicine accepts submissions of research articles, reviews, case reports, letters to editor and book reviews.