{"title":"Macrolide-resistant Mycoplasma pneumoniae is an independent risk factor for bronchial mucus plug formation in children.","authors":"Xie Chunlian, Zhou Lili, Zhang Libin, Xiao Yichun","doi":"10.1007/s00431-025-06095-8","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed to explore the characteristics of bronchial mucus plug formation and its risk factors. A total of 578 children who underwent bronchoalveolar lavage treatment between January 2022 and June 2024 at the Department of Pediatric, Women and Children's Hospital of Ganzhou were assessed in this study.The bronchoalveolar lavage fluid was tested by next-generation sequencing. The resistance genes of macrolides in Mycoplasma pneumoniae (MP) were detected by polymerase chain reaction. Data related to the basic information, clinical characteristics, and etiology were statistically analyzed. Logistic regression analysis was performed to identify the independent risk factors for bronchial mucus plug formation. There were 312 cases in the mucus plug group and 266 in the non-mucus plug group. The mucus plug group children were older, had longer hospital stays, exhibited a higher incidence of fever, experienced more complications, and had higher rates of hormone use when compared to those in the non-mucus plug group (P < 0.05). The detection rate of MP and macrolide resistance was significantly higher in the mucus plug group than in the non-mucus plug group (P < 0.05). According to the logistic regression analysis, macrolide-resistant MP (MRMP) acted as an independent risk factor for the formation of bronchial mucus plugs in children.</p><p><strong>Conclusion: </strong>Bronchial mucus plugs were common in children with MP infection, often accompanied by fever and prolonged hospitalization. MRMP was thus identified as an independent risk factor for bronchial mucus plug formation.</p><p><strong>What is known: </strong>• MP can lead to bronchial mucus plugs.</p><p><strong>What is new: </strong>• MRMP is an independent risk factor for the formation of bronchial mucus plugs.</p>","PeriodicalId":11997,"journal":{"name":"European Journal of Pediatrics","volume":"184 4","pages":"264"},"PeriodicalIF":2.6000,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930860/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Pediatrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00431-025-06095-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
Abstract
This study aimed to explore the characteristics of bronchial mucus plug formation and its risk factors. A total of 578 children who underwent bronchoalveolar lavage treatment between January 2022 and June 2024 at the Department of Pediatric, Women and Children's Hospital of Ganzhou were assessed in this study.The bronchoalveolar lavage fluid was tested by next-generation sequencing. The resistance genes of macrolides in Mycoplasma pneumoniae (MP) were detected by polymerase chain reaction. Data related to the basic information, clinical characteristics, and etiology were statistically analyzed. Logistic regression analysis was performed to identify the independent risk factors for bronchial mucus plug formation. There were 312 cases in the mucus plug group and 266 in the non-mucus plug group. The mucus plug group children were older, had longer hospital stays, exhibited a higher incidence of fever, experienced more complications, and had higher rates of hormone use when compared to those in the non-mucus plug group (P < 0.05). The detection rate of MP and macrolide resistance was significantly higher in the mucus plug group than in the non-mucus plug group (P < 0.05). According to the logistic regression analysis, macrolide-resistant MP (MRMP) acted as an independent risk factor for the formation of bronchial mucus plugs in children.
Conclusion: Bronchial mucus plugs were common in children with MP infection, often accompanied by fever and prolonged hospitalization. MRMP was thus identified as an independent risk factor for bronchial mucus plug formation.
What is known: • MP can lead to bronchial mucus plugs.
What is new: • MRMP is an independent risk factor for the formation of bronchial mucus plugs.
期刊介绍：
The European Journal of Pediatrics (EJPE) is a leading peer-reviewed medical journal which covers the entire field of pediatrics. The editors encourage authors to submit original articles, reviews, short communications, and correspondence on all relevant themes and topics.
EJPE is particularly committed to the publication of articles on important new clinical research that will have an immediate impact on clinical pediatric practice. The editorial office very much welcomes ideas for publications, whether individual articles or article series, that fit this goal and is always willing to address inquiries from authors regarding potential submissions. Invited review articles on clinical pediatrics that provide comprehensive coverage of a subject of importance are also regularly commissioned.
The short publication time reflects both the commitment of the editors and publishers and their passion for new developments in the field of pediatrics.
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EJPE is the official journal of the European Academy of Paediatrics (EAP) and publishes guidelines and statements in cooperation with the EAP.
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