[Superoxide dismutase, catalase and glutathione peroxidase activities in mice with natural lymphocytic leukemia].

Abstract

In the mice of the high leukemic strain, sick with natural lymphatic leukemia, the following parameters were determined on the 0 day, after 90, 180 and 270 days of observation: activity of the superoxide dismutase (SOD-EC1.15.1.1), glutathione peroxidase (GSH-px-EC1.11.1.9) in the blood and catalase activity in erythrocytes. It was observed that the activity of all three enzymes during the development of the leukemic process decreased. This phenomenon indicates the disturbance of the protective role of these enzymes against free radicals in leucogenesis in mice.