{"title":"Are beta-haemolytic streptococci involved in the pathogenesis of mesangial IgA-nephropathy?","authors":"S Rekola, A Bergstrand, H Bucht, A Lindberg","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>In retrospect we have found that 38 of 187 patients who fulfilled the criteria of mesangial IgA-nephropathy had possible acute glomerulonephritis at the onset of their disease. We have therefore studied anti-streptococcal antibodies (ASO and ADNAseB) prospectively. Forty-three per cent of the patients had ADNAseB greater than 800 units. Thirty-one per cent of the patients studied more than once had a fourfold or greater change in their ADNAseB titre. Thirty-three per cent of the patients had different groups of beta-haemolytic streptococci isolated from their throats. This indicates a possible role of beta-haemolytic streptococci in the pathogenesis of some cases of mesangial IgA-nephropathy.</p>","PeriodicalId":77886,"journal":{"name":"Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress","volume":"21 ","pages":"698-702"},"PeriodicalIF":0.0000,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In retrospect we have found that 38 of 187 patients who fulfilled the criteria of mesangial IgA-nephropathy had possible acute glomerulonephritis at the onset of their disease. We have therefore studied anti-streptococcal antibodies (ASO and ADNAseB) prospectively. Forty-three per cent of the patients had ADNAseB greater than 800 units. Thirty-one per cent of the patients studied more than once had a fourfold or greater change in their ADNAseB titre. Thirty-three per cent of the patients had different groups of beta-haemolytic streptococci isolated from their throats. This indicates a possible role of beta-haemolytic streptococci in the pathogenesis of some cases of mesangial IgA-nephropathy.
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