Influence of biochemical and hormonal factors on the bone histomorphometric features of uraemic patients.

Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Pub Date : 1985-01-01

A Fournier, J L Sebert, P Fohrer, P Moriniere, G Lambrey, M A Herve, P Leflon, J Gueris, M Garabedian

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Abstract

A multidimensional analysis was used to evaluate, the influence on bone histology of various biochemical and hormonal factors in 20 uraemic patients on chronic haemodialysis or haemofiltration. A positive relationship (p less than 0.1) was found between PTH and osteoclastic and osteoblastic surfaces but not with mineral apposition and bone formation rates. The mineral appositional rate which reflects the cellular activity of osteoblasts was positively related to D metabolites 25(OH)D3 and 1,25(OH)2D3 and to phosphate (p less than 0.1). Mineral appositional rate and bone formation rate were negatively related to bone aluminium (p less than 0.05). These data indicate that: 1) PTH simulates bone turnover but has no direct effect on the bone cellular activity of osteoblasts which is mainly dependent on D metabolites and phosphate; 2) mild aluminium overload not severe enough to cause osteomalacia decreases bone formation in uraemic patients. This study evaluates the role of various simultaneously measured biochemical and hormonal factors on bone histological parameters in uraemic patients.

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生化和激素因素对尿毒症患者骨组织形态学特征的影响。

采用多维分析方法评价慢性血液透析或血液滤过对20例尿毒症患者骨组织的影响。PTH与破骨细胞和成骨细胞表面呈正相关(p < 0.1)，但与矿物质附着和骨形成率无显著相关性。反映成骨细胞活性的矿物质附着率与D代谢产物25(OH)D3和1,25(OH)2D3以及磷酸盐呈正相关(p < 0.1)。矿物附着率和骨形成率与骨铝呈负相关(p < 0.05)。这些数据表明:1)甲状旁腺激素模拟骨转换，但对成骨细胞活性无直接影响，成骨细胞活性主要依赖于D代谢物和磷酸盐;2)轻度铝超载，不严重到引起骨软化，减少尿毒症患者的骨形成。本研究评估了同时测定的各种生化和激素因子对尿毒症患者骨组织参数的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

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