Effects of naloxone infusion on gonadotrophin and prolactin concentrations in patients with chronic renal failure.

Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress Pub Date : 1985-01-01

M Cossu, G B Sorba, M Maioli, P Tomasi, G Delitala

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Abstract

Serum prolactin, luteinising hormone and follicle-stimulating hormone, determined by radioimmunoassay were measured during the infusion of 10mg naloxone or saline in eight male patients with chronic renal failure on regular dialysis and in seven normal controls. Neither saline nor naloxone caused any significant change in luteinising hormone, follicle-stimulating hormone or prolactin in patients with chronic renal failure. On the contrary, luteinising hormone secretion was significantly stimulated by naloxone in normal controls. Since naloxone is a specific antagonist of opiate receptors, the results would suggest a reduced hypothalamic opiate tone in patients with chronic renal failure. The data does not support the concept that the high circulating met-encephalin reported in chronic renal failure represents the pathogenetic cause of hyperprolactinaemia in chronic renal failure.

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纳洛酮对慢性肾功能衰竭患者促性腺激素和催乳素浓度的影响。

采用放射免疫法测定8例定期透析的男性慢性肾功能衰竭患者和7例正常对照者在纳洛酮或生理盐水输注10mg时血清催乳素、促黄体生成素和促卵泡激素水平。生理盐水和纳洛酮均未引起慢性肾衰竭患者黄体生成素、促卵泡激素或催乳素的显著变化。相反，在正常对照中，纳洛酮显著刺激黄体生成素分泌。由于纳洛酮是阿片受体的特异性拮抗剂，结果表明慢性肾衰竭患者下丘脑阿片张力降低。这些数据不支持慢性肾衰竭中报告的高循环甲基脑素代表慢性肾衰竭中高泌乳素血症的致病原因的概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress

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