A comparison of the sensitivities of neonatal hircine pulmonary and femoral arterial rings to tolazoline.

Abstract

The effect of tolazoline (1 X 10(-5) M) upon the norepinephrine concentration-response relationship is compared in pulmonary and femoral arterial rings from neonatal goats. As we have reported previously in neonatal lambs, the pulmonary vessels are more sensitive to norepinephrine (pED50 7.23 +/- 0.22 for the pulmonary vs. 6.49 +/- 0.42 for the femoral). However, there is no difference in the response to tolazoline of the two vessel types (pKB for tolazoline 5.77 +/- 0.23 in the pulmonary and 5.79 +/- 0.33 in the femoral).