The prediction of acute response, remission and general outcome of neuroleptic treatment in acute schizophrenic patients.

N Nedopil, R Pflieger, E Rüther
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引用次数: 35

Abstract

The prognosis of a clinical neuroleptic treatment was prospectively examined in 26 schizophrenic patients using a predetermined set of predictors and outcome criteria. Prognosis before treatment did not discriminate significantly between patients with good and poor outcome. Significant differences of outcome were observed between the prognostic groups, if prognosis was established after 5 days of treatment. Retrospective analysis of individual predictors indicated the following rank order: initial improvement, age, duration of symptoms before treatment, sex, subjective tolerance of the treatment. The relative weight of the individual predictor in forming the prognosis is still an open question.

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急性精神分裂症患者抗精神病药物治疗的急性反应、缓解和一般预后的预测。
采用一套预先确定的预测指标和结果标准,对26例精神分裂症患者进行了临床抗精神病药物治疗的预后进行了前瞻性研究。治疗前预后在预后好与预后差患者之间无显著差异。如果在治疗5天后确定预后,则预后组之间的结果存在显著差异。对个体预测因素的回顾性分析显示:初始改善、年龄、治疗前症状持续时间、性别、治疗的主观耐受性。个体预测因子在形成预后中的相对权重仍然是一个悬而未决的问题。
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Multimethodological approach in psychiatric predictor research. Psychobiological predictors of antidepressant drug response. The prediction of acute response, remission and general outcome of neuroleptic treatment in acute schizophrenic patients. Prediction of "natural" course, relapse and prophylactic response in schizophrenic patients. Prediction of course and therapeutic response in psychiatric diseases.
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