{"title":"[Degradation of glutamic acid and proline in Clostridium sordellii under cadaveric bacteriological inspection].","authors":"W Huckenbeck, T Daldrup","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Glutamic acid (GLU) is decarboxylated to gamma-aminobutyric acid (GABA) by Clostridium sordellii isolated from a decaying human brain. The dependence of this reaction on temperature, pH and substrate concentration has been established. The pH-optimum is in the range of 5.0 to 5.2. Near optimal pH the temperature optimum is greater than 28 degrees C. At higher pH-values (6 to 7) activity is relatively independent of temperature. The similarity to results in decaying human brains (10, 11, 12) shows a good correlation between postmortem bacterial flora and GLU-degradation. Furthermore it is shown that C. sordellii produces delta-aminovaleric acid (AVA) from proline (PRO).</p>","PeriodicalId":23821,"journal":{"name":"Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology","volume":"258 1","pages":"51-61"},"PeriodicalIF":0.0000,"publicationDate":"1984-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Glutamic acid (GLU) is decarboxylated to gamma-aminobutyric acid (GABA) by Clostridium sordellii isolated from a decaying human brain. The dependence of this reaction on temperature, pH and substrate concentration has been established. The pH-optimum is in the range of 5.0 to 5.2. Near optimal pH the temperature optimum is greater than 28 degrees C. At higher pH-values (6 to 7) activity is relatively independent of temperature. The similarity to results in decaying human brains (10, 11, 12) shows a good correlation between postmortem bacterial flora and GLU-degradation. Furthermore it is shown that C. sordellii produces delta-aminovaleric acid (AVA) from proline (PRO).
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