[Sex hormone binding globulin in stimulated cycles].

Abstract

Ovulation was stimulated in 56 cycles, namely in 16 cycles with clomiphene, in 19 with clomiphene and HCG, and in 16 cycles with clomiphene, HMG and HCG. In three women there was no LH or estradiol increase following ovulation stimulation with clomiphene, but in two women stimulated by the two remaining methods there was a spontaneous LH peak before the application of HCG. Using the radioimmunologic method once a day the concentrations of LH, estradiol and SHBG in serum were determined. The concentrations of SHBG in serum do not change in all three methods of ovulation stimulation. The mean concentrations of SHBG vary between 47 and 54 mumol/l during the entire preovulatory phase of the stimulated cycle. All of these cycles were ovulatory since the preovulatory E2 peak is clearly expressed in all three methods of ovulation stimulation.