[Effect of renal polypeptides on lymphocyte activity in experimental nephritis].

Abstract

A model of experimental nephritis in Wistar rats has been used to show that the pathology mentioned induces sharp morphofunctional changes in the parenchyma of the kidneys. At the same time the state of the T-link (lymphocyte blasttransformation response to phytohemagglutinin) and B-link (a titre of serum antirenal antibodies) of the immunity were studied. It is shown that development of experimental nephritis is accompanied by intensification of the lymphocytic response to phytohemagglutinin and renal tissue antigenes with a simultaneous increase of a titre of antirenal antibodies. To correct these damages a complex of polypeptide substances isolated from the kidney parenchyma was applied. The results obtained demonstrate a normalizing effect of this complex on lymphocyte activity. A conclusion is made on possible tolerogenic action of substances of this complex.