[Changes in secretion of pituitary hormones after neuropeptide Y administration into the third cerebral ventricle].

Abstract

Neuropeptide Y (NPY) administration into the third brain ventricle of normal and castrated male rats decreases prolactin and LH secretion almost not affecting FSH. Simultaneous augmentation of hypophyseal response to LH-RH is observed. NPY effect on LH release is more pronounced in castrated animals as compared to normal ones. It is concluded that in the CNS inhibitory action of NPY prevails as regards to neuroendocrine control of gonadotropin and prolactin secretion. The obtained results allow NPY participation in feedback regulation of LH secretion in males.