{"title":"Formation by the endothelium of prostacyclin, nitric oxide and endothelin.","authors":"J R Vane, R M Botting","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Prostacyclin and nitric oxide (NO) are two labile vasorelaxant and anti-aggregatory substances which are released by receptor activation and in response to shear forces acting on endothelial cells, whereas the potent constrictor peptide, endothelin-1 (ET-1) is probably slowly released and exerts long-term control over the cardiovascular system. This review deals with the synthesis, release and pharmacological actions of prostacyclin, NO and ET-1, as well as the diseases which might result from their under- or over-production.</p>","PeriodicalId":16323,"journal":{"name":"Journal of lipid mediators","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of lipid mediators","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Prostacyclin and nitric oxide (NO) are two labile vasorelaxant and anti-aggregatory substances which are released by receptor activation and in response to shear forces acting on endothelial cells, whereas the potent constrictor peptide, endothelin-1 (ET-1) is probably slowly released and exerts long-term control over the cardiovascular system. This review deals with the synthesis, release and pharmacological actions of prostacyclin, NO and ET-1, as well as the diseases which might result from their under- or over-production.
分享
京公网安备 11010802042870号
京ICP备2023020795号-1
求助内容：
应助结果提醒方式：
扫码关注我们
