[4-Androstene-3,17-dione metabolism in vitro in the liver microsomes of species of bullhead endemic to Lake Baikal under normal conditions and in mono-oxygenase induction by 3-methylcholanthrene and aroclor 1254].

Abstract

The metabolism in vitro of 4-androstene 3,17-dione--one of the steroid hormones--has been studied in liver microsomes of three species of bullhead: Cottocomephorus grewingki Dyb., Paracottus Kneri Dyb., Paracottus Kessleri Dyb. from Lake Baikal under norm and under induction of monooxygenases by 3-methylcholanthrene and arochlore 1254. The metabolism in vitro 4-androstene 3,17-dione in liver microsomes depends on fish sex, species and gonadal maturation. The rate of androstendione hydroxylation reliably decreases at monooxydase system induction of endoplasmic reticulum in bullhead liver before spawning and during spawning periods by 3-methylcholanthrene and arochlore 1254.