K Yamamoto, K Makimura, T Sudo, K Shibuya, K Uchida, H Yamaguchi
{"title":"Experimental disseminated trichosporonosis in mice: tissue distribution and therapy with antifungal agents.","authors":"K Yamamoto, K Makimura, T Sudo, K Shibuya, K Uchida, H Yamaguchi","doi":"10.1080/02681219780001511","DOIUrl":null,"url":null,"abstract":"<p><p>Mice treated with cyclophosphamide were infected intravenously with titrated doses of Trichosporon asahii TIMM3140 or TIMM3144. Mortality and survival time correlated with inoculum size and fungal growth was found in the lung, heart, liver, spleen, kidney and brain. Fluconazole and amphotericin B prolonged survival time and reduced the CFU in the kidney, with fluconazole being superior to amphotericin B. The serum level of (1-->3)-beta-D-glucan was reduced by antifungal therapy and correlated well with the CFU/organ in kidney, but not CFU/ml in blood.</p>","PeriodicalId":77214,"journal":{"name":"Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology","volume":"35 6","pages":"411-8"},"PeriodicalIF":0.0000,"publicationDate":"1997-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/02681219780001511","citationCount":"15","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/02681219780001511","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 15
Abstract
Mice treated with cyclophosphamide were infected intravenously with titrated doses of Trichosporon asahii TIMM3140 or TIMM3144. Mortality and survival time correlated with inoculum size and fungal growth was found in the lung, heart, liver, spleen, kidney and brain. Fluconazole and amphotericin B prolonged survival time and reduced the CFU in the kidney, with fluconazole being superior to amphotericin B. The serum level of (1-->3)-beta-D-glucan was reduced by antifungal therapy and correlated well with the CFU/organ in kidney, but not CFU/ml in blood.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
