Lorin E Olson, Jeremy S Dasen, Bong Gun Ju, Jessica Tollkuhn, Michael G Rosenfeld
{"title":"Paired-like repression/activation in pituitary development.","authors":"Lorin E Olson, Jeremy S Dasen, Bong Gun Ju, Jessica Tollkuhn, Michael G Rosenfeld","doi":"10.1210/rp.58.1.249","DOIUrl":null,"url":null,"abstract":"<p><p>Pituitary gland development is controlled by signals that guide expression of specific combinations of transcription factors that dictate serial determination and differentiation events. One class of factors is paired-like homeodomain factors. Two that have been investigated are the repressor Hex1/Rpx and activator prophet of Pit-1 (Prop-1), which exert selective roles during pituitary development. The opposing actions of these factors provide one aspect of pituitary organogenesis.</p>","PeriodicalId":21099,"journal":{"name":"Recent progress in hormone research","volume":"58 ","pages":"249-61"},"PeriodicalIF":0.0000,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"22","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Recent progress in hormone research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1210/rp.58.1.249","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 22
Abstract
Pituitary gland development is controlled by signals that guide expression of specific combinations of transcription factors that dictate serial determination and differentiation events. One class of factors is paired-like homeodomain factors. Two that have been investigated are the repressor Hex1/Rpx and activator prophet of Pit-1 (Prop-1), which exert selective roles during pituitary development. The opposing actions of these factors provide one aspect of pituitary organogenesis.
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