Effects of vitamin C and E on liver enzymes and biochemical parameters of rabbits exposed to aflatoxin B1.

Veterinary and human toxicology Pub Date : 2004-08-01
Ali Ziya Karakilcik, Mustafa Zerin, Oktay Arslan, Yasar Nazligul, Huseyin Vural
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Abstract

Hepatotoxic substances such as aflatoxin B1 (AFB1) produce free radical reactions during biotransformation damage to liver cells. Vitamins C and E are important natural antioxidants suppressing free radicals. This study investigated the effects of vitamins C and E on liver enzymes and other biochemical parameters in rabbits experimentally exposed to AFB1. The first group was control and fed the diet with dimethyl sulfoxide; the second group received 0.1 mg AFB1/kg diet; the third group received vitamin C (100 mg L-ascorbic acid/kg diet); the fourth group received vitamin E (100 mg alpha-tocopherol/kg diet); and the fifth group received vitamin C+vitamin E (100 mg L-ascorbic acid/kg diet+100 mg alpha-tocopherol/kg diet). Diets of the second, third, fourth and fifth groups were mixed with 0.1 mg AFB/kg diet) and feedings were continued for 10 w. Levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, creatine phosphokinase and lactate dehydrogenase after receiving AFB1 were significantly increased, while activities of aspartate transaminase, alanine transaminase, amylase, creatine phosphokinase and lactate dehydrogenase in groups receiving AFB1 + vitamins C, E or C+E were significantly lower than that of the AFB1-alone group. Although of the activity of alkaline phosphatase increased with AFB1 exposure, it decreased with vitamin C administration. Levels of urea, triglyceride, cholesterol and albumin were affected by AFB1 and AFB1+vitaminC. AFB1 affected some liver enzymes and other biochemical parameters, but vitamins C, E and C+E partially prevented an increase in these liver enzymes and some the biochemical parameters induced by AFB1.

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维生素C和E对黄曲霉毒素B1暴露家兔肝酶及生化指标的影响。
肝毒性物质如黄曲霉毒素B1 (AFB1)在肝细胞生物转化损伤过程中产生自由基反应。维生素C和E是抑制自由基的重要天然抗氧化剂。本研究探讨了维生素C和E对AFB1暴露家兔肝酶等生化指标的影响。第一组为对照,饲粮中添加二甲亚砜;第二组饲喂0.1 mg AFB1/kg日粮;第三组给予维生素C (100 mg l -抗坏血酸/kg日粮);第四组给予维生素E (α -生育酚100 mg /kg日粮);第五组给予维生素C+维生素E (100 mg l -抗坏血酸/kg日粮+100 mg α -生育酚/kg日粮)。第二、第三、第四和第五组饲粮中分别添加0.1 mg AFB/kg饲粮,连续饲喂10 w。AFB1组的天冬氨酸转氨酶、丙氨酸转氨酶、碱性磷酸酶、肌酸磷酸激酶和乳酸脱氢酶水平显著提高,而AFB1 +维生素C组的天冬氨酸转氨酶、丙氨酸转氨酶、淀粉酶、肌酸磷酸激酶和乳酸脱氢酶活性显著提高。E或C+E均显著低于单独afb1组。碱性磷酸酶的活性随AFB1的增加而增加,随维生素C的增加而降低。尿素、甘油三酯、胆固醇和白蛋白水平受AFB1和AFB1+维生素c的影响。AFB1对部分肝酶及其他生化指标有影响,而维生素C、E和C+E部分阻止了AFB1诱导的这些肝酶及部分生化指标的升高。
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