A screening study of xylitol binding in vitro to activated charcoal.

Veterinary and human toxicology Pub Date : 2004-12-01
R B Cope
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Abstract

Ingestion of foods containing the sweetener xylitol by dogs results in a significant, and often sustained, insulin-mediated hypoglycemic crisis. The efficacy of activated charcoal for gastrointestinal decontamination following xylitol ingestion is unknown. This screening study examined the effect of pH and incubation time on the in vitro binding of xylitol to activated charcoal. The mean percentage activated charcoal binding ranged between 8 and 23%. Mean percentage binding of xylitol at pH 3 was significantly higher (p < 0.05) than the binding of xylitol at pH 1 or pH 5 following 40 or 60 min of incubation with an aQueous 200 g/L activated charcoal slurry. These results suggest binding of xylitol to activated charcoal is relatively low; however, activated charcoal administration may still be beneficial in some canine acute oral xylitol exposures.

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木糖醇体外与活性炭结合的筛选研究。
狗摄入含有甜味剂木糖醇的食物会导致胰岛素介导的严重且通常持续的低血糖危机。木糖醇摄入后,活性炭对胃肠道净化的功效尚不清楚。本筛选研究考察了pH和培养时间对木糖醇与活性炭体外结合的影响。活性炭结合的平均百分比在8%到23%之间。用200 g/L的活性炭液孵育40或60分钟后,木糖醇在pH 3下的平均结合率显著高于pH 1或pH 5下的木糖醇结合率(p < 0.05)。这些结果表明木糖醇与活性炭的结合相对较低;然而,活性炭管理可能仍然有利于一些犬急性口服木糖醇暴露。
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Chemical disasters. Epichlorohydrin. Alternatives to drugs. A screening study of xylitol binding in vitro to activated charcoal. Two plant fish-poisons in Lebanon.
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