{"title":"A pivoting algorithm for metabolic networks in the presence of thermodynamic constraints.","authors":"R Nigam, S Liang","doi":"10.1109/csb.2005.6","DOIUrl":null,"url":null,"abstract":"<p><p>A linear programming algorithm is presented to constructively compute thermodynamically feasible fluxes and change in chemical potentials of reactions for a metabolic network. It is based on physical laws of mass conservation and the second law of thermodynamics that all chemical reactions should satisfy. As a demonstration, the algorithm has been applied to the core metabolic pathway of E. coli.</p>","PeriodicalId":87417,"journal":{"name":"Proceedings. IEEE Computational Systems Bioinformatics Conference","volume":" ","pages":"259-67"},"PeriodicalIF":0.0000,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/csb.2005.6","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings. IEEE Computational Systems Bioinformatics Conference","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/csb.2005.6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
A linear programming algorithm is presented to constructively compute thermodynamically feasible fluxes and change in chemical potentials of reactions for a metabolic network. It is based on physical laws of mass conservation and the second law of thermodynamics that all chemical reactions should satisfy. As a demonstration, the algorithm has been applied to the core metabolic pathway of E. coli.
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