{"title":"[Significance of angiogenesis in malignant tumors].","authors":"Lukás Smolej, Petra Beneová","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Angiogenesis, i.e. development of new vessels from preexisting ones, plays a key role in the development and progression of malignant tumors. Increased angiogenesis is the hallmark of virtully all types of cancer and has been identified as an independent adverse prognostic factor in various solid tumors and hematological malignancies. This review summarizes current knowledge about angiogenic process, describes methods of angiogenesis assessment and appreciates antiangiogenic therapy which offers new and perspective options in the treatment of malignancies.</p>","PeriodicalId":79548,"journal":{"name":"Acta medica (Hradec Kralove). Supplementum","volume":"48 2","pages":"69-72"},"PeriodicalIF":0.0000,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta medica (Hradec Kralove). Supplementum","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Angiogenesis, i.e. development of new vessels from preexisting ones, plays a key role in the development and progression of malignant tumors. Increased angiogenesis is the hallmark of virtully all types of cancer and has been identified as an independent adverse prognostic factor in various solid tumors and hematological malignancies. This review summarizes current knowledge about angiogenic process, describes methods of angiogenesis assessment and appreciates antiangiogenic therapy which offers new and perspective options in the treatment of malignancies.
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